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87.654 3.647 87.654 3.449 87.727 3.377 c
87.889 3.267 l
88.381 2.942 88.381 2.85 88.381 2.143 c
h
101.841 1.581 m
102.602 1.581 102.856 1.598 102.91 1.706 c
102.948 1.779 102.984 1.923 102.984 2.177 c
102.984 3.266 101.969 4.336 100.409 4.336 c
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99.065 -2.303 97.994 -0.741 97.994 1.092 c
97.994 1.544 98.012 1.581 98.484 1.581 c
h
98.32 2.123 m
98.194 2.123 98.194 2.177 98.194 2.213 c
98.212 2.812 99.139 3.795 100.209 3.795 c
101.262 3.795 101.607 3.159 101.607 2.65 c
101.607 2.413 101.553 2.341 101.498 2.303 c
101.354 2.195 100.952 2.123 99.61 2.123 c
h
108.355 4.336 m
105.343 4.336 103.966 2.251 103.966 0.292 c
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108.517 3.721 109.188 3.251 109.587 2.76 c
109.661 2.668 109.751 2.63 109.841 2.63 c
110.059 2.63 110.24 2.978 110.24 3.303 c
110.24 3.613 110.115 3.903 109.969 4.029 c
109.479 4.244 108.771 4.336 108.355 4.336 c
115.066 4.336 m
112.927 4.336 111.205 2.704 111.205 0.417 c
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118.749 2.816 117.101 4.336 115.066 4.336 c
117.193 0.292 m
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116.572 3.795 117.193 1.833 117.193 0.292 c
122.325 7.55 m
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122.359 -2.519 122.325 -2.339 122.325 -1.033 c
h
128.368 4.336 m
126.224 4.336 124.504 2.704 124.504 0.417 c
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130.49 0.292 m
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129.875 3.795 130.49 1.833 130.49 0.292 c
139.308 3.683 m
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137.385 -2.521 136.642 -2.577 136.023 -2.577 c
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134.752 -1.288 135.335 -0.941 135.553 -0.815 c
135.771 -0.833 136.023 -0.869 136.35 -0.869 c
138.655 -0.869 139.396 0.763 139.396 2.015 c
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140.669 2.942 l
140.938 2.978 140.976 3.591 140.777 3.683 c
h
137.603 -3.645 m
138.909 -3.645 139.67 -4.117 139.67 -5.223 c
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135.335 -7.167 134.553 -6.35 134.553 -5.369 c
134.553 -4.68 134.988 -4.117 135.424 -3.845 c
135.677 -3.682 136.402 -3.645 136.985 -3.645 c
h
136.624 -0.345 m
135.749 -0.345 134.97 0.489 134.97 1.779 c
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142.065 3.267 l
142.556 2.942 142.556 2.85 142.556 2.143 c
h
143.154 8.255 m
142.608 8.255 142.173 7.874 142.173 7.276 c
142.173 6.787 142.538 6.369 143.098 6.369 c
143.607 6.369 144.059 6.661 144.059 7.314 c
144.059 7.82 143.699 8.255 143.154 8.255 c
150.48 4.336 m
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147.778 -3.01 148.668 -3.318 149.627 -3.318 c
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151.916 -1.834 151.373 -2.303 150.318 -2.303 c
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147.398 2.724 148.631 3.721 149.901 3.721 c
150.646 3.721 151.317 3.251 151.716 2.76 c
151.787 2.668 151.878 2.63 151.97 2.63 c
152.188 2.63 152.37 2.978 152.37 3.303 c
152.37 3.613 152.244 3.903 152.096 4.029 c
151.607 4.244 150.898 4.336 150.48 4.336 c
164.528 -3.354 m
168.031 -3.354 170.823 -0.689 170.823 2.978 c
170.823 6.17 168.718 9.199 164.528 9.199 c
160.789 9.199 158.07 6.424 158.07 2.794 c
158.07 -0.472 160.497 -3.354 164.528 -3.354 c
164.763 -2.795 m
161.188 -2.795 159.88 0.689 159.88 3.375 c
159.88 7.352 162.332 8.638 164.218 8.638 c
167.687 8.638 169.01 5.407 169.01 2.413 c
169.01 -1.162 166.942 -2.795 164.763 -2.795 c
173.328 -1.033 m
173.328 -2.339 173.312 -2.519 172.637 -2.611 c
172.257 -2.665 l
172.13 -2.757 172.167 -3.066 172.293 -3.12 c
172.802 -3.086 173.346 -3.063 173.999 -3.063 c
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175.777 -3.066 175.811 -2.757 175.683 -2.665 c
175.359 -2.611 l
174.706 -2.503 174.667 -2.339 174.667 -1.033 c
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174.667 2.271 174.706 2.524 174.94 2.834 c
175.198 3.177 175.795 3.469 176.486 3.469 c
177.72 3.469 178.19 2.706 178.19 1.671 c
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178.19 -2.339 178.174 -2.503 177.502 -2.611 c
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177.029 -2.757 177.065 -3.066 177.195 -3.12 c
177.682 -3.086 178.226 -3.063 178.879 -3.063 c
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174.74 3.413 174.667 3.503 174.667 3.611 c
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174.667 4.554 174.577 4.59 174.505 4.59 c
174.143 4.318 173.11 3.848 172.693 3.701 c
172.603 3.647 172.603 3.449 172.675 3.377 c
172.837 3.267 l
173.328 2.942 173.328 2.85 173.328 2.143 c
h
186.116 4.336 m
183.104 4.336 181.731 2.251 181.731 0.292 c
181.731 -0.891 182.145 -1.78 182.78 -2.395 c
183.411 -3.01 184.302 -3.318 185.263 -3.318 c
186.317 -3.318 187.677 -2.813 188.293 -1.47 c
188.275 -1.306 188.113 -1.179 187.965 -1.215 c
187.552 -1.834 187.006 -2.303 185.954 -2.303 c
184.012 -2.303 183.033 -0.617 183.033 0.799 c
183.033 2.724 184.266 3.721 185.536 3.721 c
186.279 3.721 186.951 3.251 187.35 2.76 c
187.422 2.668 187.512 2.63 187.604 2.63 c
187.822 2.63 188.003 2.978 188.003 3.303 c
188.003 3.613 187.877 3.903 187.731 4.029 c
187.244 4.244 186.535 4.336 186.116 4.336 c
192.831 4.336 m
190.689 4.336 188.968 2.704 188.968 0.417 c
188.968 -1.852 190.598 -3.318 192.687 -3.318 c
194.956 -3.318 196.514 -1.688 196.514 0.581 c
196.514 2.816 194.864 4.336 192.831 4.336 c
194.956 0.292 m
194.956 -1.109 194.466 -2.777 192.867 -2.777 c
191.269 -2.777 190.526 -0.999 190.526 0.653 c
190.526 2.65 191.417 3.795 192.613 3.795 c
194.337 3.795 194.956 1.833 194.956 0.292 c
200.089 7.55 m
200.089 8.349 200.123 9.255 200.141 9.799 c
199.959 9.909 l
199.308 9.563 198.459 9.293 198.002 9.148 c
198.002 8.784 l
198.186 8.675 l
198.729 8.349 198.747 8.239 198.747 7.168 c
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198.747 -2.339 198.729 -2.519 198.058 -2.611 c
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201.304 -3.066 201.34 -2.757 201.212 -2.665 c
200.777 -2.611 l
200.123 -2.519 200.089 -2.339 200.089 -1.033 c
h
206.131 4.336 m
203.988 4.336 202.268 2.704 202.268 0.417 c
202.268 -1.852 203.898 -3.318 205.986 -3.318 c
208.254 -3.318 209.814 -1.688 209.814 0.581 c
209.814 2.816 208.163 4.336 206.131 4.336 c
208.254 0.292 m
208.254 -1.109 207.765 -2.777 206.166 -2.777 c
204.569 -2.777 203.824 -0.999 203.824 0.653 c
203.824 2.65 204.713 3.795 205.914 3.795 c
207.637 3.795 208.254 1.833 208.254 0.292 c
217.069 3.683 m
216.672 3.683 216.547 3.719 215.964 3.973 c
215.545 4.155 214.912 4.336 214.223 4.336 c
212.609 4.336 211.267 3.159 211.267 1.598 c
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212.625 -0.688 212.535 -0.833 212.443 -0.941 c
212.134 -1.27 211.794 -1.578 211.484 -1.776 c
211.284 -1.922 211.214 -1.994 211.214 -2.085 c
211.214 -2.722 211.828 -3.338 212.535 -3.518 c
212.697 -3.628 212.553 -3.791 212.391 -3.953 c
211.972 -4.372 211.466 -4.842 211.158 -5.17 c
211.031 -5.315 210.957 -5.551 210.957 -5.843 c
210.957 -6.751 211.738 -7.946 213.967 -7.946 c
216.33 -7.946 218.485 -6.496 218.485 -4.516 c
218.485 -2.704 216.961 -2.521 215.947 -2.521 c
215.149 -2.521 214.405 -2.577 213.787 -2.577 c
212.935 -2.577 212.517 -2.233 212.517 -1.812 c
212.517 -1.288 213.096 -0.941 213.314 -0.815 c
213.532 -0.833 213.787 -0.869 214.115 -0.869 c
216.416 -0.869 217.161 0.763 217.161 2.015 c
217.161 2.323 217.161 2.632 217.123 2.942 c
218.433 2.942 l
218.703 2.978 218.737 3.591 218.541 3.683 c
h
215.367 -3.645 m
216.672 -3.645 217.435 -4.117 217.435 -5.223 c
217.435 -6.26 216.364 -7.167 214.75 -7.167 c
213.096 -7.167 212.317 -6.35 212.317 -5.369 c
212.317 -4.68 212.753 -4.117 213.188 -3.845 c
213.44 -3.682 214.167 -3.645 214.75 -3.645 c
h
214.388 -0.345 m
213.514 -0.345 212.733 0.489 212.733 1.779 c
212.733 3.012 213.388 3.813 214.259 3.813 c
215.367 3.813 215.875 2.778 215.875 1.542 c
215.875 0.435 215.367 -0.345 214.388 -0.345 c
219.774 -7.582 m
220.191 -7.582 220.626 -7.419 220.936 -6.729 c
221.823 -4.754 223.311 -1.596 223.908 -0.382 c
224.927 1.704 l
225.544 2.994 225.868 3.519 226.469 3.627 c
226.777 3.683 l
226.904 3.793 226.886 4.066 226.739 4.138 c
226.233 4.102 225.816 4.081 225.362 4.081 c
224.891 4.081 224.348 4.102 223.768 4.138 c
223.624 4.084 223.603 3.773 223.732 3.683 c
224.292 3.591 l
224.617 3.537 224.727 3.409 224.727 3.283 c
224.727 3.084 224.491 2.413 224.092 1.468 c
223.477 0.036 l
223.149 -0.709 222.859 -1.27 222.805 -1.306 c
222.732 -1.27 222.386 -0.308 222.278 -0.02 c
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221.589 1.959 221.17 3.14 221.17 3.357 c
221.17 3.483 221.316 3.537 221.571 3.591 c
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222.151 3.773 222.133 4.084 221.985 4.138 c
221.407 4.102 220.896 4.081 220.409 4.081 c
219.812 4.081 219.266 4.102 218.687 4.138 c
218.543 4.084 218.523 3.773 218.631 3.683 c
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219.304 -6.078 218.977 -6.316 218.977 -6.803 c
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f
Q
q 1 0 0 1 3037.5151 2375.3384 cm
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h
0.412 -0.718 m
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h
f
Q
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h
S
Q
Q
0 0 0 0 k
1070.333 39.685 2089.981 2193.323 re
f
q
0 0 3200 2400 re
W n
q 1 0 0 1 40.7701 2277.48 cm
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9.66 19.53 10.85 17.92 10.85 16.345 c
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h
28 -1.015 m
33.6 -1.015 36.82 3.57 36.82 11.235 c
36.82 18.9 33.6 23.485 28 23.485 c
22.4 23.485 19.18 18.9 19.18 11.235 c
19.18 3.57 22.4 -1.015 28 -1.015 c
28 3.115 m
25.305 3.115 23.765 6.02 23.765 11.235 c
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48.615 5.425 51.275 8.715 52.78 10.85 c
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43.155 23.485 40.425 20.055 y
40.18 19.775 40.25 19.355 40.46 19.145 c
42.14 17.465 l
42.42 17.185 42.805 17.185 43.085 17.465 c
43.89 18.34 45.325 19.53 47.005 19.53 c
49.525 19.53 50.715 17.92 50.715 16.345 c
50.715 15.155 50.015 13.79 48.93 12.46 c
46.585 9.345 42.175 3.605 39.865 0.805 c
h
61.844 0 m
61.844 -0.35 62.124 -0.665 62.509 -0.665 c
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58.029 18.9 l
57.889 18.76 57.819 18.55 57.854 18.27 c
58.064 16.555 l
58.099 16.24 58.449 16.03 58.764 16.1 c
61.844 16.765 l
h
f
Q
q 1 0 0 1 41.6101 2338.1951 cm
0 0 m
0.7 -0.665 3.29 -2.73 7.7 -2.73 c
12.635 -2.73 15.75 0.595 15.75 4.2 c
15.75 8.715 11.83 10.745 8.435 12.11 c
5.6 13.265 4.305 14.385 4.305 16.03 c
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12.67 16.275 13.195 16.555 13.475 16.975 c
14.805 18.97 l
15.05 19.32 14.945 19.915 14.595 20.125 c
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1.96 3.71 1.365 3.71 1.085 3.22 c
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18.48 9.835 m
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40.005 9.1 l
40.005 9.45 39.725 9.765 39.375 9.765 c
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32.27 9.765 31.99 9.485 31.99 9.1 c
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35.455 2.73 l
34.755 2.45 33.25 1.855 31.29 1.855 c
26.88 1.855 23.415 5.53 23.415 9.87 c
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33.18 17.99 35.035 17.29 36.54 15.96 c
36.855 15.68 37.17 15.68 37.45 15.96 c
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39.9 18.515 39.865 18.935 39.585 19.215 c
37.205 21.245 34.195 22.47 31.045 22.47 c
24.08 22.47 18.48 16.835 18.48 9.835 c
43.399 9.835 m
43.399 2.835 48.964 -2.73 55.964 -2.73 c
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68.564 16.835 62.964 22.47 55.964 22.47 c
48.964 22.47 43.399 16.835 43.399 9.835 c
47.949 9.835 m
47.949 14.245 51.554 17.92 55.964 17.92 c
60.374 17.92 64.014 14.245 64.014 9.835 c
64.014 5.425 60.374 1.82 55.964 1.82 c
51.554 1.82 47.949 5.425 47.949 9.835 c
f
Q
q 1 0 0 1 189.435 2289.03 cm
0 0 m
0 -7 5.565 -12.565 12.565 -12.565 c
19.565 -12.565 25.165 -7 25.165 0 c
25.165 7 19.565 12.635 12.565 12.635 c
5.565 12.635 0 7 0 0 c
4.55 0 m
4.55 4.41 8.155 8.085 12.565 8.085 c
16.975 8.085 20.615 4.41 20.615 0 c
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29.75 -11.55 m
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34.3 3.5 l
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45.885 -2.835 l
45.85 -2.835 l
31.29 12.635 l
30.415 12.635 l
30.065 12.635 29.75 12.355 29.75 12.005 c
h
68.984 -12.075 m
69.054 -12.355 69.334 -12.565 69.614 -12.565 c
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70.524 -12.565 70.664 -12.39 70.769 -12.18 c
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87.674 12.285 87.394 12.04 87.324 11.795 c
83.754 -2.17 l
83.614 -2.17 l
78.014 12.25 l
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76.439 12.635 76.264 12.46 76.194 12.25 c
70.629 -2.17 l
70.489 -2.17 l
66.849 11.795 l
66.779 12.04 66.499 12.285 66.219 12.285 c
62.999 12.285 l
62.509 12.285 62.229 11.935 62.369 11.445 c
h
94.079 0 m
94.079 -7 99.644 -12.565 106.644 -12.565 c
113.644 -12.565 119.244 -7 119.244 0 c
119.244 7 113.644 12.635 106.644 12.635 c
99.644 12.635 94.079 7 94.079 0 c
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122.219 -11.41 m
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128.694 1.575 l
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142.939 1.575 l
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145.424 12.39 145.214 12.635 144.829 12.635 c
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143.954 12.635 143.779 12.495 143.674 12.285 c
135.974 -4.235 l
135.869 -4.235 l
128.169 12.285 l
128.064 12.495 127.854 12.635 127.574 12.635 c
127.014 12.635 l
126.629 12.635 126.419 12.39 126.384 12.11 c
h
154.383 -11.55 m
154.383 -11.9 154.663 -12.215 155.048 -12.215 c
169.293 -12.215 l
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158.933 -1.89 l
167.578 -1.89 l
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168.243 1.68 l
168.243 2.03 167.928 2.345 167.578 2.345 c
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158.933 8.085 l
169.293 8.085 l
169.678 8.085 169.958 8.4 169.958 8.75 c
169.958 11.62 l
169.958 11.97 169.678 12.285 169.293 12.285 c
155.048 12.285 l
154.663 12.285 154.383 11.97 154.383 11.62 c
h
174.963 -11.55 m
174.963 -11.9 175.278 -12.215 175.628 -12.215 c
178.813 -12.215 l
179.198 -12.215 179.478 -11.9 179.478 -11.55 c
179.478 3.5 l
179.513 3.5 l
194.143 -12.565 l
194.983 -12.565 l
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195.648 11.62 l
195.648 11.97 195.333 12.285 194.983 12.285 c
191.763 12.285 l
191.378 12.285 191.098 11.97 191.098 11.62 c
191.098 -2.835 l
191.063 -2.835 l
176.503 12.635 l
175.628 12.635 l
175.278 12.635 174.963 12.355 174.963 12.005 c
h
200.478 5.32 m
201.843 5.32 l
202.088 5.32 202.403 5.565 202.473 5.845 c
203.908 11.41 l
204.048 11.9 203.733 12.285 203.278 12.285 c
200.478 12.285 l
200.128 12.285 199.813 11.97 199.813 11.62 c
199.813 5.985 l
199.813 5.635 200.128 5.32 200.478 5.32 c
206.498 -9.835 m
207.198 -10.5 209.788 -12.565 214.198 -12.565 c
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212.098 3.43 210.803 4.55 210.803 6.195 c
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215.808 8.645 218.468 6.895 218.748 6.72 c
219.168 6.44 219.693 6.72 219.973 7.14 c
221.303 9.135 l
221.548 9.485 221.443 10.08 221.093 10.29 c
220.393 10.815 217.663 12.635 214.093 12.635 c
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206.218 1.785 209.508 -0.315 212.798 -1.645 c
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232.677 0 m
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253.817 8.4 l
254.097 8.68 254.097 9.1 253.782 9.38 c
251.402 11.515 248.847 12.635 245.312 12.635 c
238.312 12.635 232.677 7 232.677 0 c
255.812 -12.215 m
258.857 -12.215 l
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272.052 -7.735 l
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266.382 12.635 266.207 12.46 266.102 12.25 c
255.217 -11.305 l
255.007 -11.76 255.287 -12.215 255.812 -12.215 c
263.302 -3.85 m
266.732 3.85 l
266.837 3.85 l
270.337 -3.85 l
h
281.607 -11.55 m
281.607 -11.9 281.922 -12.215 282.272 -12.215 c
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285.842 -12.215 286.122 -11.9 286.122 -11.55 c
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286.157 3.5 l
300.787 -12.565 l
301.627 -12.565 l
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298.407 12.285 l
298.022 12.285 297.742 11.97 297.742 11.62 c
297.742 -2.835 l
297.707 -2.835 l
283.147 12.635 l
282.272 12.635 l
281.922 12.635 281.607 12.355 281.607 12.005 c
h
306.877 0 m
306.877 -7 312.512 -12.565 319.512 -12.565 c
322.627 -12.565 325.637 -11.48 328.017 -9.17 c
328.262 -8.925 328.332 -8.47 328.052 -8.225 c
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328.017 8.4 l
328.297 8.68 328.297 9.1 327.982 9.38 c
325.602 11.515 323.047 12.635 319.512 12.635 c
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332.601 -11.55 m
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346.461 1.68 l
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337.151 8.085 l
347.511 8.085 l
347.896 8.085 348.176 8.4 348.176 8.75 c
348.176 11.62 l
348.176 11.97 347.896 12.285 347.511 12.285 c
333.266 12.285 l
332.881 12.285 332.601 11.97 332.601 11.62 c
h
353.181 -11.55 m
353.181 -11.9 353.461 -12.215 353.846 -12.215 c
357.066 -12.215 l
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366.271 -11.9 l
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366.306 -2.31 l
369.351 -1.085 371.486 1.54 371.486 4.76 c
371.486 8.925 368.056 12.285 363.856 12.285 c
353.846 12.285 l
353.461 12.285 353.181 11.97 353.181 11.62 c
h
357.766 1.12 m
357.766 8.085 l
363.471 8.085 l
365.326 8.085 366.936 6.545 366.936 4.69 c
366.936 2.73 365.326 1.12 363.471 1.12 c
h
374.163 6.582 m
374.163 2.542 377.448 -0.744 381.488 -0.744 c
385.528 -0.744 388.834 2.542 388.834 6.582 c
388.834 10.622 385.528 13.927 381.488 13.927 c
377.448 13.927 374.163 10.622 374.163 6.582 c
375.754 6.582 m
375.754 9.765 378.325 12.316 381.488 12.316 c
384.671 12.316 387.222 9.765 387.222 6.582 c
387.222 3.419 384.671 0.848 381.488 0.848 c
378.325 0.848 375.754 3.419 375.754 6.582 c
378.754 3.256 m
378.754 3.052 378.917 2.868 379.142 2.868 c
380.141 2.868 l
380.366 2.868 380.529 3.052 380.529 3.256 c
380.529 5.439 l
381.59 5.439 l
382.488 3.154 l
382.549 3.011 382.692 2.868 382.855 2.868 c
383.957 2.868 l
384.243 2.868 384.426 3.133 384.304 3.419 c
383.365 5.541 l
383.998 5.847 384.814 6.459 384.814 7.806 c
384.814 9.398 383.569 10.336 382.304 10.336 c
379.142 10.336 l
378.917 10.336 378.754 10.153 378.754 9.948 c
h
380.468 6.949 m
380.468 8.622 l
382.08 8.622 l
382.57 8.622 382.917 8.275 382.917 7.786 c
382.917 7.316 382.57 6.949 382.08 6.949 c
h
f
Q
q 1 0 0 1 198.815 2335.8501 cm
0 0 m
0.105 -0.21 0.28 -0.385 0.595 -0.385 c
0.945 -0.385 l
1.26 -0.385 1.435 -0.21 1.54 0 c
12.39 23.555 l
12.6 24.01 12.32 24.465 11.795 24.465 c
8.225 24.465 l
7.91 24.465 7.7 24.255 7.63 24.08 c
0.91 9.03 l
0.665 9.03 l
-6.055 24.08 l
-6.125 24.255 -6.335 24.465 -6.65 24.465 c
-10.22 24.465 l
-10.745 24.465 -11.025 24.01 -10.815 23.555 c
h
15.575 0.63 m
15.575 0.28 15.89 -0.035 16.24 -0.035 c
19.495 -0.035 l
19.845 -0.035 20.16 0.28 20.16 0.63 c
20.16 23.8 l
20.16 24.15 19.845 24.465 19.495 24.465 c
16.24 24.465 l
15.89 24.465 15.575 24.15 15.575 23.8 c
h
26.529 0.63 m
26.529 0.28 26.809 -0.035 27.194 -0.035 c
30.414 -0.035 l
30.764 -0.035 31.079 0.28 31.079 0.63 c
31.079 9.555 l
34.964 9.555 l
39.619 0.28 l
39.689 0.14 39.864 -0.035 40.179 -0.035 c
43.854 -0.035 l
44.449 -0.035 44.694 0.525 44.449 0.98 c
39.654 9.87 l
42.699 11.095 44.834 13.72 44.834 16.94 c
44.834 21.105 41.404 24.465 37.204 24.465 c
27.194 24.465 l
26.809 24.465 26.529 24.15 26.529 23.8 c
h
31.114 13.3 m
31.114 20.265 l
36.819 20.265 l
38.674 20.265 40.284 18.725 40.284 16.87 c
40.284 14.91 38.674 13.3 36.819 13.3 c
h
53.129 0.63 m
53.129 0.28 53.444 -0.035 53.794 -0.035 c
57.049 -0.035 l
57.399 -0.035 57.714 0.28 57.714 0.63 c
57.714 20.265 l
63.069 20.265 l
63.454 20.265 63.734 20.58 63.734 20.93 c
63.734 23.8 l
63.734 24.15 63.454 24.465 63.069 24.465 c
47.774 24.465 l
47.389 24.465 47.109 24.15 47.109 23.8 c
47.109 20.93 l
47.109 20.58 47.389 20.265 47.774 20.265 c
53.129 20.265 l
h
67.024 9.24 m
67.024 3.92 71.259 -0.385 76.754 -0.385 c
82.284 -0.385 86.519 3.92 86.519 9.24 c
86.519 23.8 l
86.519 24.15 86.204 24.465 85.854 24.465 c
82.529 24.465 l
82.144 24.465 81.864 24.15 81.864 23.8 c
81.864 9.45 l
81.864 6.51 79.799 4.165 76.754 4.165 c
73.709 4.165 71.679 6.51 71.679 9.485 c
71.679 23.8 l
71.679 24.15 71.399 24.465 71.014 24.465 c
67.689 24.465 l
67.339 24.465 67.024 24.15 67.024 23.8 c
h
89.599 -0.035 m
92.644 -0.035 l
93.204 -0.035 93.519 0.315 93.659 0.665 c
95.374 4.445 l
105.839 4.445 l
107.554 0.665 l
107.799 0.175 108.044 -0.035 108.569 -0.035 c
111.614 -0.035 l
112.139 -0.035 112.419 0.42 112.209 0.875 c
101.429 24.43 l
101.324 24.64 101.184 24.815 100.834 24.815 c
100.484 24.815 l
100.169 24.815 99.994 24.64 99.889 24.43 c
89.004 0.875 l
88.794 0.42 89.074 -0.035 89.599 -0.035 c
97.089 8.33 m
100.519 16.03 l
100.624 16.03 l
104.124 8.33 l
h
115.393 0.63 m
115.393 0.28 115.673 -0.035 116.058 -0.035 c
128.868 -0.035 l
129.253 -0.035 129.533 0.28 129.533 0.63 c
129.533 3.5 l
129.533 3.85 129.253 4.165 128.868 4.165 c
119.943 4.165 l
119.943 23.8 l
119.943 24.15 119.628 24.465 119.278 24.465 c
116.058 24.465 l
115.673 24.465 115.393 24.15 115.393 23.8 c
h
138.213 -0.035 m
141.258 -0.035 l
141.818 -0.035 142.133 0.315 142.273 0.665 c
143.988 4.445 l
154.453 4.445 l
156.168 0.665 l
156.413 0.175 156.658 -0.035 157.183 -0.035 c
160.228 -0.035 l
160.753 -0.035 161.033 0.42 160.823 0.875 c
150.043 24.43 l
149.938 24.64 149.798 24.815 149.448 24.815 c
149.098 24.815 l
148.783 24.815 148.608 24.64 148.503 24.43 c
137.618 0.875 l
137.408 0.42 137.688 -0.035 138.213 -0.035 c
145.703 8.33 m
149.133 16.03 l
149.238 16.03 l
152.738 8.33 l
h
164.008 0.63 m
164.008 0.28 164.323 -0.035 164.673 -0.035 c
167.858 -0.035 l
168.243 -0.035 168.523 0.28 168.523 0.63 c
168.523 15.68 l
168.558 15.68 l
183.188 -0.385 l
184.028 -0.385 l
184.378 -0.385 184.693 -0.105 184.693 0.245 c
184.693 23.8 l
184.693 24.15 184.378 24.465 184.028 24.465 c
180.808 24.465 l
180.423 24.465 180.143 24.15 180.143 23.8 c
180.143 9.345 l
180.108 9.345 l
165.548 24.815 l
164.673 24.815 l
164.323 24.815 164.008 24.535 164.008 24.185 c
h
191.062 0.63 m
191.062 0.28 191.377 -0.035 191.727 -0.035 c
194.912 -0.035 l
195.297 -0.035 195.577 0.28 195.577 0.63 c
195.577 15.68 l
195.612 15.68 l
210.242 -0.385 l
211.082 -0.385 l
211.432 -0.385 211.747 -0.105 211.747 0.245 c
211.747 23.8 l
211.747 24.15 211.432 24.465 211.082 24.465 c
207.862 24.465 l
207.477 24.465 207.197 24.15 207.197 23.8 c
207.197 9.345 l
207.162 9.345 l
192.602 24.815 l
191.727 24.815 l
191.377 24.815 191.062 24.535 191.062 24.185 c
h
217.767 9.24 m
217.767 3.92 222.002 -0.385 227.497 -0.385 c
233.027 -0.385 237.262 3.92 237.262 9.24 c
237.262 23.8 l
237.262 24.15 236.947 24.465 236.597 24.465 c
233.272 24.465 l
232.887 24.465 232.607 24.15 232.607 23.8 c
232.607 9.45 l
232.607 6.51 230.542 4.165 227.497 4.165 c
224.452 4.165 222.422 6.51 222.422 9.485 c
222.422 23.8 l
222.422 24.15 222.142 24.465 221.757 24.465 c
218.432 24.465 l
218.082 24.465 217.767 24.15 217.767 23.8 c
h
240.342 -0.035 m
243.387 -0.035 l
243.947 -0.035 244.262 0.315 244.402 0.665 c
246.117 4.445 l
256.582 4.445 l
258.297 0.665 l
258.542 0.175 258.787 -0.035 259.312 -0.035 c
262.357 -0.035 l
262.882 -0.035 263.162 0.42 262.952 0.875 c
252.172 24.43 l
252.067 24.64 251.927 24.815 251.577 24.815 c
251.227 24.815 l
250.912 24.815 250.737 24.64 250.632 24.43 c
239.747 0.875 l
239.537 0.42 239.817 -0.035 240.342 -0.035 c
247.832 8.33 m
251.262 16.03 l
251.367 16.03 l
254.867 8.33 l
h
266.137 0.63 m
266.137 0.28 266.417 -0.035 266.802 -0.035 c
279.612 -0.035 l
279.997 -0.035 280.277 0.28 280.277 0.63 c
280.277 3.5 l
280.277 3.85 279.997 4.165 279.612 4.165 c
270.687 4.165 l
270.687 23.8 l
270.687 24.15 270.372 24.465 270.022 24.465 c
266.802 24.465 l
266.417 24.465 266.137 24.15 266.137 23.8 c
h
289.936 0.77 m
289.866 0.28 290.146 -0.035 290.601 -0.035 c
293.751 -0.035 l
294.066 -0.035 294.346 0.245 294.381 0.49 c
296.411 13.755 l
296.516 13.755 l
302.711 0 l
302.816 -0.21 302.991 -0.385 303.306 -0.385 c
303.936 -0.385 l
304.251 -0.385 304.461 -0.21 304.531 0 c
310.656 13.755 l
310.761 13.755 l
312.826 0.49 l
312.896 0.245 313.176 -0.035 313.491 -0.035 c
316.676 -0.035 l
317.131 -0.035 317.411 0.28 317.306 0.77 c
313.176 24.29 l
313.141 24.57 312.931 24.815 312.546 24.815 c
311.986 24.815 l
311.671 24.815 311.496 24.675 311.391 24.465 c
303.691 7.945 l
303.586 7.945 l
295.886 24.465 l
295.781 24.675 295.571 24.815 295.291 24.815 c
294.731 24.815 l
294.346 24.815 294.136 24.57 294.101 24.29 c
h
322.101 0.63 m
322.101 0.28 322.381 -0.035 322.766 -0.035 c
337.011 -0.035 l
337.396 -0.035 337.676 0.28 337.676 0.63 c
337.676 3.5 l
337.676 3.85 337.396 4.165 337.011 4.165 c
326.651 4.165 l
326.651 10.29 l
335.296 10.29 l
335.646 10.29 335.961 10.57 335.961 10.955 c
335.961 13.86 l
335.961 14.21 335.646 14.525 335.296 14.525 c
326.651 14.525 l
326.651 20.265 l
337.011 20.265 l
337.396 20.265 337.676 20.58 337.676 20.93 c
337.676 23.8 l
337.676 24.15 337.396 24.465 337.011 24.465 c
322.766 24.465 l
322.381 24.465 322.101 24.15 322.101 23.8 c
h
342.681 0.63 m
342.681 0.28 342.961 -0.035 343.346 -0.035 c
357.591 -0.035 l
357.976 -0.035 358.256 0.28 358.256 0.63 c
358.256 3.5 l
358.256 3.85 357.976 4.165 357.591 4.165 c
347.231 4.165 l
347.231 10.29 l
355.876 10.29 l
356.226 10.29 356.541 10.57 356.541 10.955 c
356.541 13.86 l
356.541 14.21 356.226 14.525 355.876 14.525 c
347.231 14.525 l
347.231 20.265 l
357.591 20.265 l
357.976 20.265 358.256 20.58 358.256 20.93 c
358.256 23.8 l
358.256 24.15 357.976 24.465 357.591 24.465 c
343.346 24.465 l
342.961 24.465 342.681 24.15 342.681 23.8 c
h
366.551 0.63 m
366.551 0.28 366.866 -0.035 367.216 -0.035 c
370.471 -0.035 l
370.821 -0.035 371.136 0.28 371.136 0.63 c
371.136 20.265 l
376.491 20.265 l
376.876 20.265 377.156 20.58 377.156 20.93 c
377.156 23.8 l
377.156 24.15 376.876 24.465 376.491 24.465 c
361.196 24.465 l
360.811 24.465 360.531 24.15 360.531 23.8 c
360.531 20.93 l
360.531 20.58 360.811 20.265 361.196 20.265 c
366.551 20.265 l
h
380.795 0.63 m
380.795 0.28 381.11 -0.035 381.46 -0.035 c
384.715 -0.035 l
385.065 -0.035 385.38 0.28 385.38 0.63 c
385.38 23.8 l
385.38 24.15 385.065 24.465 384.715 24.465 c
381.46 24.465 l
381.11 24.465 380.795 24.15 380.795 23.8 c
h
391.75 0.63 m
391.75 0.28 392.065 -0.035 392.415 -0.035 c
395.6 -0.035 l
395.985 -0.035 396.265 0.28 396.265 0.63 c
396.265 15.68 l
396.3 15.68 l
410.93 -0.385 l
411.77 -0.385 l
412.12 -0.385 412.435 -0.105 412.435 0.245 c
412.435 23.8 l
412.435 24.15 412.12 24.465 411.77 24.465 c
408.55 24.465 l
408.165 24.465 407.885 24.15 407.885 23.8 c
407.885 9.345 l
407.85 9.345 l
393.29 24.815 l
392.415 24.815 l
392.065 24.815 391.75 24.535 391.75 24.185 c
h
417.055 12.18 m
417.055 5.18 422.655 -0.35 429.62 -0.35 c
434.695 -0.35 438.3 1.925 y
438.44 2.03 438.58 2.205 438.58 2.485 c
438.58 11.445 l
438.58 11.795 438.3 12.11 437.95 12.11 c
431.23 12.11 l
430.845 12.11 430.565 11.83 430.565 11.445 c
430.565 8.68 l
430.565 8.33 430.845 8.05 431.23 8.05 c
434.03 8.05 l
434.03 5.075 l
433.33 4.795 431.825 4.2 429.865 4.2 c
425.455 4.2 421.99 7.875 421.99 12.215 c
421.99 16.59 425.455 20.335 429.83 20.335 c
431.755 20.335 433.61 19.635 435.115 18.305 c
435.43 18.025 435.745 18.025 436.025 18.305 c
438.195 20.58 l
438.475 20.86 438.44 21.28 438.16 21.56 c
435.78 23.59 432.77 24.815 429.62 24.815 c
422.655 24.815 417.055 19.18 417.055 12.18 c
f
Q
Q
71 w 10 M
q 1 0 0 1 1095.3334 2173.2168 cm
0 0 m
665.039 0 l
S
Q
BT
/T1_0 1 Tf
40 0 0 40 1115.3334 2158.7168 Tm
[(Intr)18(oduction)]TJ
-0.011 Tc 0.011 Tw 68 0 0 68 63.8358 2049.083 Tm
[(C)5(o)1(m)-4(p)1(a)-5(r)-7(a)-1(t)-13(iv)17(e)-11( t)7(o)2(l)-3(e)-3(r)-7(a)-5(b)-3(ilit)-31(y)-11( )]TJ
-0.013 Tc 0.013 Tw 0 -1.103 TD
[(a)-7(n)-6(d)-13( d)-3(o)4(s)-3(e)-13( mod)-6(i)-9(\037c)-4(a)-3(t)-15(io)-3(n)-4(s)-13( o)3(f)-13( )]TJ
-0.01 Tc 0.01 Tw T*
[(po)3(l)-6(y)7(\()-5(A)-1(D)3(P)32(-r)-1(i)-1(b)3(o)7(se)22(\))-10( po)3(l)-6(y)-6(m)-2(e)-2(r)-6(a)-1(se)-10( )]TJ
-0.009 Tc 0.009 Tw T*
[(in)-3(h)-1(ib)-1(i)2(t)9(o)1(r)-10(s)-9( in)-9( o)23(v)17(a)-3(ri)1(a)-3(n)-9( ca)-3(n)3(c)-2(e)-1(r)1(:)-9( )]TJ
0 Tc 0 Tw ( )Tj
-0.006 Tc 0.006 Tw T*
[(a)-6( re)9(t)-8(r)4(o)11(sp)2(e)6(c)-2(t)-8(i)5(v)22(e)-6( c)6(o)4(h)6(o)4(r)-26(t)-6( stud)-6(y)-6( )]TJ
-0.009 Tc 0.009 Tw T*
[(o)7(f)-9( U)5(S)-9( h)-1(e)5(al)2(t)-11(h)3(ca)-3(r)-3(e)-9( cl)1(ai)2(m)1(s)-9( d)-2(a)1(t)-8(a)]TJ
/T1_1 1 Tf
-0.003 Tc 0.003 Tw 27 0 0 27 63.8358 1598.8893 Tm
[(R)7(e)1(b)2(e)-5(cca)-3( A)-9(r)8(e)-1(n)4(d)16(,)]TJ
0 Tc 0 Tw 15.741 0 0 15.741 253.2241 1607.8802 Tm
(1)Tj
-0.02 Tc 0.02 Tw 27 0 0 27 261.9761 1598.8893 Tm
[( D)-13(a)4(v)-10(i)-12(d)-20( M)-20( O)8(\222M)-11(a)-15(l)-6(l)-11(ey)60(,)]TJ
0 Tc 0 Tw 15.741 0 0 15.741 484.4012 1607.8802 Tm
(2)Tj
-0.01 Tc 0.01 Tw 27 0 0 27 493.1531 1598.8893 Tm
[( S)-3(u)-5(s)-8(a)-6(n)-1(a)-10( Ba)-6(n)-1(e)-10(r)-7(je)-12(e)9(,)]TJ
0 Tc 0 Tw 15.741 0 0 15.741 709.7388 1607.8802 Tm
(3)Tj
-0.012 Tc 0.012 Tw 27 0 0 27 718.4908 1598.8893 Tm
[( K)-12(im)-4(m)-2(i)-3(e)-12( M)-5(c)-4(L)-22(a)-1(u)-5(r)-8(in)6(,)]TJ
0 Tc 0 Tw 15.741 0 0 15.741 940.8866 1607.8802 Tm
(4)Tj
27 0 0 27 949.6385 1598.8893 Tm
( )Tj
-0.006 Tc 0.006 Tw -32.808 -1.259 Td
[(Ri)2(ch)3(a)-4(r)3(d)-6( D)1(a)18(v)4(i)2(ds)-1(o)1(n)12(,)]TJ
0 Tc 0 Tw 15.741 0 0 15.741 281.6631 1573.8802 Tm
(5)Tj
-0.009 Tc 0.009 Tw 27 0 0 27 290.4151 1564.8893 Tm
[( G)-8(r)-5(\341)-4(i)3(nne)-9( Lo)-2(n)-2(g)]TJ
0 Tc 0 Tw 15.741 0 0 15.741 459.1953 1573.8802 Tm
(5)Tj
27 0 0 27 467.9473 1564.8893 Tm
( )Tj
11.077 0 0 11.077 63.8358 1513.2163 Tm
(1)Tj
19 0 0 19 69.2878 1506.8893 Tm
[(U)8(n)9(i)8(v)24(e)-2(r)-9(s)5(i)6(t)-15(y o)13(f A)-4(l)7(a)3(b)7(a)2(m)4(a)-2(, B)6(i)8(r)-1(m)8(i)9(n)5(g)6(h)6(a)1(m)14(, AL)-10(, U)11(S)6(A)2(; )]TJ
11.077 0 0 11.077 458.1385 1513.2163 Tm
(2)Tj
19 0 0 19 464.2286 1506.8893 Tm
[(T)-2(h)6(e O)-1(h)9(i)7(o S)3(t)2(a)7(t)23(e U)8(n)9(i)8(v)24(e)-2(r)-9(s)5(i)6(t)-15(y)76(, C)3(o)6(l)10(u)6(m)7(b)5(u)2(s)8(, O)6(H)12(, U)11(S)6(A)2(; )]TJ
11.077 0 0 11.077 871.3133 1513.2163 Tm
(3)Tj
19 0 0 19 877.3713 1506.8893 Tm
[(T)-2(h)6(e R)8(o)23(y)19(a)2(l )]TJ
-42.818 -1.263 Td
[(M)6(ar)-9(s)3(d)6(en N)8(H)6(S F)22(o)6(u)6(n)5(d)6(a)7(t)13(i)7(o)5(n T)83(r)-1(u)2(s)3(t a)1(n)5(d I)11(n)4(s)3(t)13(i)6(t)14(u)3(t)23(e o)13(f C)12(a)1(n)5(c)2(e)-2(r R)8(e)-2(s)4(ear)7(c)4(h)15(, L)6(o)5(n)5(d)6(o)5(n)15(, U)9(K)5(; )]TJ
11.077 0 0 11.077 733.2853 1489.2163 Tm
(4)Tj
19 0 0 19 739.3875 1482.8893 Tm
[(A)-2(s)3(t)10(r)2(a)-16(Z)14(en)6(e)-4(c)1(a P)16(h)6(ar)-1(m)4(a)7(c)2(e)1(u)3(t)13(i)5(c)1(a)3(l)6(s L)7(P)139(, )]TJ
-35.555 -1.263 Td
[(Ga)2(i)6(t)12(h)6(e)-2(r)-9(s)5(b)5(u)4(r)7(g)15(, M)9(D)37(, U)11(S)6(A)2(; )]TJ
11.077 0 0 11.077 272.0938 1465.2163 Tm
(5)Tj
19 0 0 19 278.1463 1458.8893 Tm
[(A)-2(s)3(t)10(r)2(a)-16(Z)14(en)6(e)-4(c)1(a P)16(h)6(ar)-1(m)4(a)7(c)2(e)1(u)3(t)13(i)5(c)1(a)3(l)6(s L)7(P)139(, C)12(a)1(m)7(b)2(r)1(i)5(d)5(g)5(e)17(, U)9(K )]TJ
ET
0 0 0 0 K
1.865 w 4 M
q 1 0 0 1 65.2638 1638.4219 cm
0 0 m
957.697 0 l
S
Q
q 1 0 0 1 63.8092 1539.8457 cm
0 0 m
959.152 0 l
S
Q
BT
/T1_2 1 Tf
20 0 0 20 61.3471 107.6414 Tm
[(Contact: rar)18(end@uabmc.edu)]TJ
0 -1.5 TD
[(Pr)18(esented at the Society of Gynecologic Oncology V)-6(irtual Annual Meeting, Mar)18(ch 19\22625, 2021)]TJ
ET
64 2150.417 978.252 55.655 re
f
BT
0.415 1 0.4 0.219 k
/T1_0 1 Tf
-0.038 Tc 0.038 Tw 30.07 0 0 31 76.2291 2166.8818 Tm
[(P)-18(o)-32(s)-42(t)-35(e)-40(r)-38( 10)-51(4)-55(8)-27(7)]TJ
/CS0 cs 1 scn
/T1_2 1 Tf
0 Tc 0 Tw 20 0 0 20 1094.0901 2103.9197 Tm
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Thr)Tj
1.39 0 Td
[(ee P)74(ARPi \(olaparib, niraparib, and rucaparib\) ar)18(e appr)18(oved as )]TJ
-1.39 -1.25 Td
[(maintenance tr)18(eatment of platinum-sensitive r)18(ecurr)18(ent OC r)18(egar)18(dless )]TJ
0 -1.25 TD
(of biomarker status.)Tj
11.66 0 0 11.66 1302.5876 2060.5796 Tm
(1\2266)Tj
20 0 0 20 1321.3835 2053.9197 Tm
[( P)74(ARPi ar)18(e also appr)18(oved for use in the \037rst-line )]TJ
-9.515 -1.25 Td
[(maintenance setting and as a tr)18(eatment option for women with r)18(ecurr)18(ent )]TJ
T*
[(BRCA-mutated or homologous r)18(ecombination de\037cient \(at least thir)18(d or )]TJ
T*
[(fourth line, r)18(espectively\) tumors.)]TJ
11.66 0 0 11.66 1402.9861 1985.5797 Tm
(1\2263)Tj
20 0 0 20 1421.782 1978.9197 Tm
[( See Supplementary T)111(able 1 for details )]TJ
-14.535 -1.25 Td
[(of appr)18(oval timelines.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(In P)Tj
1.593 0 Td
(ARPi clinical trials, the most common adverse events \(AEs\) that most )Tj
-1.593 -1.25 Td
[(often led to dose modi\037cations wer)18(e hematologic toxicities;)]TJ
11.66 0 0 11.66 1638.6045 1893.5797 Tm
(4\2267)Tj
20 0 0 20 1657.4004 1886.9197 Tm
( other )Tj
-26.316 -1.25 Td
[(common AEs included gastr)18(ointestinal disor)18(ders, fatigue, and infection, )]TJ
T*
[(consistent with limited r)18(eal-world evidence fr)18(om clinical practice.)]TJ
11.66 0 0 11.66 1680.8435 1843.5797 Tm
(8\22610)Tj
/CS0 cs 1 scn
/GS0 gs
20 0 0 20 1094.0901 1794.9197 Tm
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Real-world evidence of P)Tj
10.671 0 Td
(ARPi tolerability and dose modi\037cations is )Tj
-10.671 -1.25 Td
[(curr)18(ently lacking.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(The primary objective of this study was to describe the pr)Tj
24.579 0 Td
(evalence )Tj
-24.579 -1.25 Td
[(of pr)18(especi\037ed CEIs and dose modi\037cations among women with )]TJ
T*
[(OC pr)18(escribed one of the thr)18(ee licensed P)74(ARPi in maintenance )]TJ
T*
[(and tr)18(eatment settings.)]TJ
ET
0 0 0 0 k
/GS0 gs
64.648 353.224 964.225 1046.501 re
f
0.415 1 0.4 0.219 K
0.932 w
q 1 0 0 1 64.648 353.224 cm
0 0 m
964.225 0 l
964.225 1046.501 l
0 1046.501 l
h
S
Q
q
0 0 3200 2400 re
W n
71 w 10 M
q 1 0 0 1 99.5704 1328.7933 cm
0 0 m
899 0 l
S
Q
Q
BT
/T1_0 1 Tf
40 0 0 40 119.5704 1314.2933 Tm
(Objectives)Tj
ET
q
0 0 3200 2400 re
W n
71 w 10 M
q 1 0 0 1 99.5704 953.0198 cm
0 0 m
899 0 l
S
Q
Q
BT
/T1_0 1 Tf
40 0 0 40 119.5704 938.5198 Tm
(Conclusions)Tj
0.415 1 0.4 0.219 k
/T1_1 1 Tf
36 0 0 36 99.5705 854.323 Tm
(\225)Tj
( )Tj
0.889 0 Td
(T)Tj
0.463 0 Td
[(o our knowledge, this is the lar)28(gest r)18(eal-world )]TJ
-0.463 -1.139 Td
[(comparison of P)74(ARPi therapy in women with OC. )]TJ
-0.889 -1.611 Td
(\225)Tj
( )Tj
0.889 0 Td
(The r)Tj
2.26 0 Td
[(esults suggest dif)18(fer)18(ences in the risk of )]TJ
-2.26 -1.139 Td
[(experiencing a CEI between the licensed P)74(ARPi.)]TJ
-0.889 -1.611 Td
(\225)Tj
( )Tj
0.889 0 Td
(Dif)Tj
1.204 0 Td
[(fer)18(ences wer)18(e also observed between P)74(ARPi in )]TJ
-1.204 -1.139 Td
(the likelihood of dose modi\037cations and ability to )Tj
0 -1.139 TD
[(r)18(eceive continuous therapy)74(.)]TJ
-0.889 -1.611 Td
(\225)Tj
0.111 Tw ( )Tj
-0.004 Tw 1 0 Td
(Further r)Tj
3.793 0 Td
[(esear)18(ch is r)18(equir)18(ed to assess the in\036uence )]TJ
0 Tw 18.941 0 Td
( )Tj
-22.845 -1.139 Td
[(of medication adher)18(ence on long-term )]TJ
T*
[(ef)18(fectiveness and how best to support patients )]TJ
T*
[(r)18(eceiving P)74(ARPi.)]TJ
-0.889 23.247 Td
(\225)Tj
( )Tj
0.889 0 Td
(The primary aim of this study was to characterize )Tj
T*
(tolerability)Tj
4.518 0 Td
[(, in terms of clinical events of inter)18(est \(CEIs\) )49( )]TJ
-4.518 -1.139 Td
[(and dose modi\037cations, in a lar)28(ge r)18(eal-world )]TJ
T*
(population of patients with ovarian cancer \(OC\) )Tj
T*
[(r)18(eceiving poly\(ADP-ribose\) polymerase inhibitors )]TJ
T*
[(\(P)74(ARPi\) in the USA.)]TJ
ET
71 w 10 M
q 1 0 0 1 1095.3333 1559.1831 cm
0 0 m
665.039 0 l
S
Q
BT
0 0 0 0 k
/T1_0 1 Tf
40 0 0 40 1115.3333 1544.6831 Tm
(Methods)Tj
/CS0 cs 1 scn
/T1_2 1 Tf
20 0 0 20 1094.0901 1485.5118 Tm
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(This was a longitudinal, r)Tj
10.558 0 Td
[(etr)18(ospective, cohort analysis of claims data )]TJ
-10.558 -1.25 Td
[(fr)18(om the USA MarketScan)]TJ
11.66 0 0 11.66 1356.3474 1467.1719 Tm
(\256)Tj
20 0 0 20 1365.6752 1460.5118 Tm
[( Commer)18(cial and Medicar)18(e Supplemental )]TJ
-11.729 -1.25 Td
(Databases.)Tj
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(W)Tj
0.889 0 Td
(omen \(aged \03618 years\) with OC who \037rst initiated olaparib, nirap\
arib, )Tj
-0.889 -1.25 Td
[(or rucaparib \(new P)74(ARPi users\) between January 1, 2017 and May 31, )]TJ
0 -1.25 TD
[(2019 wer)18(e included.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Baseline characteristics wer)Tj
11.93 0 Td
[(e measur)18(ed during the 6 months prior to )]TJ
-11.93 -1.25 Td
[(starting a P)74(ARPi \(pr)18(e-index period\), and patients wer)18(e observed for )]TJ
T*
[(at least 30 days after the \037rst outpatient P)74(ARPi pr)18(escription \(index )]TJ
T*
(date\) until \037rst CEI, end of observation period \(June 30, 2019\), e\
nd of )Tj
T*
[(continuous enr)18(ollment, or death, whichever occurr)18(ed \037rst.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Participant characteristics at baseline ar)Tj
17.042 0 Td
[(e r)18(eported using mean )]TJ
-17.042 -1.25 Td
[(\(standar)18(d deviation [SD]\), per)18(centage \(number\), and/or median \(range\).)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Sixteen pr)Tj
4.316 0 Td
[(ede\037ned CEIs based on the known safety pr)18(o\037les of )]TJ
-4.316 -1.25 Td
[(the P)74(ARPi \(Figur)18(e 1\) wer)18(e identi\037ed fr)18(om claims data based on )]TJ
T*
[(Inter)-18(national Classi\037cation of Diseases \(ICD\) 9/10 code criteria.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Dose was calculated for each P)Tj
13.524 0 Td
(ARPi pharmacy claim as \(quantity )Tj
-0.002 Tw -13.524 -1.25 Td
[(supplied x drug str)18(ength\)/days\222 supply and was r)18(ounded to the near)18(est )]TJ
0 Tw T*
(50 mg.)Tj
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Highest indicated doses wer)Tj
12.188 0 Td
[(e taken fr)18(om the pr)18(escribing information )]TJ
-12.188 -1.25 Td
[(for each P)74(ARPi as 600, 800, 300, and 1200 mg/day for olaparib )]TJ
T*
(tablets, olaparib capsules, niraparib capsules, and rucaparib tablets, )Tj
T*
[(r)18(espectively.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
0.51 0 Td
( )Tj
0 0 0 1 k
/GS1 gs
1.34 0 Td
(T)Tj
0.01 Tc 0.455 0 Td
[(o assess persistence and adher)18(ence, we focused on the subgr)18(oup)10( )]TJ
-0.455 -1.25 Td
[(of patients with at least 6 months of follow-up in claims, as with)10( )]TJ
T*
[(pr)18(evious peer)55(-r)18(eviewed studies.)]TJ
-0.01 Tw 11.66 0 0 11.66 1408.8468 748.1718 Tm
(11)Tj
0 Tc 0 Tw 20 0 0 20 1421.9293 741.5118 Tm
( )Tj
/CS0 cs 1 scn
/GS0 gs
-16.392 -2.1 Td
(\225)Tj
0.51 0 Td
( )Tj
0 0 0 1 k
/GS1 gs
0.01 Tc 1.34 0 Td
(Persistence \(which may be an indication of tr)Tj
19.622 0 Td
[(eatment interruptions or)10( )]TJ
-19.622 -1.25 Td
[(discontinuations\) was measur)18(ed as the per)18(centage of patients with)10( )]TJ
T*
[(no index P)74(ARPi r)18(egimen tr)18(eatment gaps of >90 days out of those)10( )]TJ
T*
[(with at least 6 months of continuous enr)18(ollment.)]TJ
-0.01 Tw 11.66 0 0 11.66 1552.9646 631.1718 Tm
(11)Tj
/CS0 cs 1 scn
/GS0 gs
0 Tc 0 Tw 20 0 0 20 1094.0901 582.5118 Tm
(\225)Tj
0.51 0 Td
( )Tj
0 0 0 1 k
/GS1 gs
0.01 Tc -0.01 Tw 1.34 0 Td
(Adher)Tj
0 Tw 2.607 0 Td
[(ence \(which may be an indicator of dosing changes,)10( )]TJ
-2.607 -1.25 Td
[(interruptions or discontinuations\) was measur)18(ed as the per)18(centage of)10( )]TJ
T*
[(patients with a medication possession ratio \(MPR; ratio of the sum of)10( )]TJ
T*
(days\222 supply during the \037xed 6-month follow-up\) of \03680%.)Tj
0 Tc 11.66 0 0 11.66 1642.1436 514.1718 Tm
(11)Tj
/CS0 cs 1 scn
/GS0 gs
20 0 0 20 1094.0901 465.5118 Tm
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Chi-squar)Tj
4.204 0 Td
[(ed or Fisher\222)111(s exact tests wer)18(e used to evaluate the )]TJ
-4.204 -1.25 Td
[(statistical signi\037cance of dif)18(fer)18(ences for categorical variables and )]TJ
T*
(t-tests for continuous variables. )Tj
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
0.49 0 Td
( )Tj
0 0 0 1 k
/GS1 gs
-0.01 Tc 1.36 0 Td
(Dose modi\037cation, persistence, and descriptive incidence of CEIs wer)Tj
0 Tc 29.216 0 Td
(e )Tj
-0.01 Tc -29.216 -1.25 Td
[(summarized by P)74(ARPi r)18(egimen; odds ratios \(ORs\) and 95% con\037dence)-10( )]TJ
T*
[(intervals \(CIs\) wer)18(e calculated to compar)18(e the likelihood of experiencing)-10( )]TJ
0 Tc 30.144 0 Td
( )Tj
-30.144 -1.25 Td
[(CEIs between P)74(ARPi.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(Multivariable Cox pr)Tj
8.483 0 Td
[(oportional hazar)18(ds r)18(egr)18(ession models compar)18(ed )]TJ
-8.483 -1.25 Td
[(the pr)18(obabilities of experiencing CEIs or discontinuation, taking )]TJ
T*
[(r)18(elevant CEIs at baseline, index P)74(ARPi r)18(egimen, Charlson Comorbidity )]TJ
T*
[(Index scor)18(e, prior tr)18(eatment with bevacizumab, and cancer)55(-r)18(elated )]TJ
T*
(surgery during the baseline period into account. )Tj
/CS0 cs 1 scn
/GS0 gs
-1.85 -2.1 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.85 0 Td
(See Supplementary Materials for full details.)Tj
ET
1 0.748 0.382 0.261 k
/GS0 gs
1785.843 2102.537 662.001 106 re
f
1 0.748 0.382 0.261 K
55 w
q 1 0 0 1 1785.843 2181.3289 cm
0 0 m
662.001 0 l
S
Q
BT
0 0 0 0 k
/T1_0 1 Tf
22 0 0 22 1805.843 2171.8289 Tm
[(Figur)18(e 1. Odds ratios \(95% CI\) for comparison of clinical )]TJ
0 -1.136 TD
[(events of inter)18(est in women with ovarian cancer r)18(eceiving )]TJ
0 -1.136 TD
(olaparib, niraparib or rucaparib )Tj
ET
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-649.949 0 l
-649.949 -21 l
-522.265 -21 l
0 -21 l
h
f
Q
q 1 0 0 1 2440.6458 1968.34 cm
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-649.949 -21 l
-522.265 -21 l
-257.28 -21 l
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-85.959 -21 l
0 -21 l
h
f
Q
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-649.949 -34.037 l
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-163.023 -34.037 l
-85.959 -34.037 l
0 -34.037 l
h
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-163.023 -33.487 l
-85.959 -33.487 l
0 -33.487 l
h
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-649.949 0 l
-649.949 -20.999 l
-522.265 -20.999 l
-257.28 -20.999 l
-163.023 -20.999 l
-85.959 -20.999 l
0 -20.999 l
h
f
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q 1 0 0 1 2440.6458 1780.1652 cm
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-85.958 0 l
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-649.948 -20.999 l
-522.265 -20.999 l
-257.279 -20.999 l
-163.023 -20.999 l
-85.958 -20.999 l
0 -20.999 l
h
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q 1 0 0 1 2440.6458 1737.9556 cm
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-522.265 -20.024 l
-257.279 -20.024 l
-163.023 -20.024 l
-85.958 -20.024 l
0 -20.024 l
h
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q 1 0 0 1 2440.6458 1696.9321 cm
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-522.265 -20.999 l
-257.28 -20.999 l
-163.023 -20.999 l
-85.959 -20.999 l
0 -20.999 l
h
f
Q
q 1 0 0 1 2440.6458 1654.9325 cm
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-649.949 0 l
-649.949 -20.998 l
-522.265 -20.998 l
-257.28 -20.998 l
-163.023 -20.998 l
-85.959 -20.998 l
0 -20.998 l
h
f
Q
q 1 0 0 1 2440.6458 1615.2369 cm
0 0 m
-649.949 0 l
-649.949 -20.998 l
-522.265 -20.998 l
-522.265 -20.999 l
-257.28 -20.999 l
-163.023 -20.999 l
-85.959 -20.999 l
0 -20.999 l
h
f
Q
BT
0 0 0 1 k
/T1_3 1 Tf
-0.015 Tc 0.015 Tw 8.9694 0 0 8.9694 1797.8767 1954.4413 Tm
(\037\036\035\034\033\032)Tj
-0.001 -2.24 Td
(\031\030\027\026\034\025\026\024\023\022\026\021\035\036\033\032\020\032\
\036\017\020\021\016\032\022\035\016\035\022\020\022\027\032\036\r\f\013\
\r\033\026\036)Tj
-0.001 -2.384 Td
(\n\035\013\t\026\021\035\036\033\032\b\036\035\013\022\027\026\021\035\036\
\033\032)Tj
-0.001 -2.283 Td
(\037\007\n\b\007\006\005)Tj
/T1_4 1 Tf
11.2117 0 0 11.2117 1794.2072 1864.869 Tm
(\037\036\035\034\033)Tj
/T1_3 1 Tf
8.9694 0 0 8.9694 1797.8696 1808.8203 Tm
(\004\023\021\035\027\022\035\036\r\033\026\036)Tj
-0.001 -2.355 Td
(\003\032\013\r\035\032\b\002\026\034\033\022\033\036\001)Tj
-0.001 -2.283 Td
(\032\022\033\001\013\035)Tj
-0.001 -2.366 Td
(\037\027\022\030\027\032\016\001\033\032)Tj
-0.001 -2.313 Td
(\201\026\036\r\022\033\021\032\022\033\026\036)Tj
-0.001 -2.301 Td
(\006\033\032\027\027\030\035\032)Tj
-0.001 -2.355 Td
(\037\024\013\022\035\020\t\033\017\036\035\023\020\033\036\215\013\027\023\
)Tj
-0.001 -2.283 Td
(\217\036\r\026\034\036\033\032)Tj
-0.001 -2.355 Td
(\006\035\027\034\032\022\033\022\033\r\b\027\032\r\030\b\021\030\026\022\
\026\r\035\036\r\033\022\033\002\033\022\023)Tj
-0.001 -2.226 Td
(\220\036\035\013\034\026\036\033\022\033\r)Tj
-0.001 -2.298 Td
(\031\027\032\036\r\032\034\033\036\033\022\033\r)Tj
ET
1 0.6 0.1 0.53 k
q 1 0 0 1 2364.5391 1577.7925 cm
0 0 m
-2.722 4.739 l
-5.444 0 l
h
f
Q
1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 2364.5391 1577.7925 cm
0 0 m
-2.722 4.739 l
-5.444 0 l
0 0 l
h
S
Q
0.28 0 1 0 k
2284.677 1577.923 -4.457 4.582 re
f
0.28 0 1 0 K
q 1 0 0 1 2284.677 1577.9227 cm
0 0 m
-4.457 0 l
-4.457 4.582 l
0 4.582 l
h
S
Q
q
1790.252 1546.923 657.435 534.413 re
W n
0.16 1 0.11 0.43 k
q 1 0 0 1 2208.7498 1580.2133 cm
0 0 m
0 -1.182 -0.941 -2.138 -2.1 -2.138 c
-3.259 -2.138 -4.2 -1.182 -4.2 0 c
-4.2 1.182 -3.259 2.138 -2.1 2.138 c
-0.941 2.138 0 1.182 0 0 c
f
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0.16 1 0.11 0.43 K
0.63 w 1 j
q 1 0 0 1 2208.7498 1580.2133 cm
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-3.259 -2.138 -4.2 -1.182 -4.2 0 c
-4.2 1.182 -3.259 2.138 -2.1 2.138 c
-0.941 2.138 0 1.182 0 0 c
h
S
Q
Q
BT
0 0 0 1 k
/T1_3 1 Tf
7.8482 0 0 7.8482 2213.854 1577.1135 Tm
[(\003\033\027\032\021\032\027\033\025\b\026\016\032\021\032\027\033\025)-1850(\235\013\024\032\021\032\027\033\025\b\026\016\032\021\032\027\033\025)-1824(\003\033\027\032\021\032\027\033\025\b\027\013\024\032\021\032\027\033\025\
)]TJ
ET
0 0 0 1 K
0.561 w 8 M
q 1 0 0 1 1973.2296 1586.0416 cm
0 0 m
0 463.28 l
S
Q
10 M
q 1 0 0 1 1928.3761 1585.4109 cm
0 0 m
268.624 0 l
S
Q
q 1 0 0 1 1928.3761 1585.4109 cm
0 0 m
0 -3.246 l
44.829 0 m
44.829 -3.246 l
89.658 0 m
89.658 -3.246 l
134.312 0 m
134.312 -3.246 l
179.141 0 m
179.141 -3.246 l
223.795 0 m
223.795 -3.246 l
268.624 0 m
268.624 -3.246 l
S
Q
BT
/T1_4 1 Tf
11.2117 0 0 11.2117 1794.2072 2014.8624 Tm
(\032\031\030)Tj
ET
0 0 0 0.7 K
0.841 w
q 1 0 0 1 2073.02 2025.2871 cm
0 0 m
-54.986 0 l
0 0 m
108.291 0 l
S
Q
q 1 0 0 1 1998.2463 2018.7977 cm
0 0 m
-28.167 0 l
0 0 m
55.203 0 l
S
Q
q 1 0 0 1 2021.0115 2012.3079 cm
0 0 m
-43.299 0 l
0 0 m
84.227 0 l
S
Q
1 0.6 0.1 0.53 k
q 1 0 0 1 2025.9888 2009.7224 cm
0 0 m
-3.92 6.526 l
-7.84 0 l
h
f
Q
1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 2025.9888 2009.7224 cm
0 0 m
-3.92 6.526 l
-7.84 0 l
0 0 l
h
S
Q
BT
0 0 0 1 k
/T1_3 1 Tf
3.435 Tc -3.435 Tw 11.2117 0 0 11.2117 1926.246 1569.4558 Tm
(\240\255\200\202\203\204\205)Tj
/T1_4 1 Tf
-0.015 Tc 0.015 Tw 9.17 -1.612 Td
(\037\027\026\025\024\023\022\026\021\020\017)Tj
23.291 46.099 Td
(\037\027\026\025\024\023\022\026\021\020\017)Tj
-44.238 -7.745 Td
(\016\034\r\f\036\013\n\013\t\b\007)Tj
ET
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0.841 w
q 1 0 0 1 1991.9424 1986.7162 cm
0 0 m
-22.29 0 l
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25.228 0 l
S
Q
0.28 0 1 0 k
1992.103 1983.335 -6.415 6.56 re
f
0.28 0 1 0 K
1.121 w
q 1 0 0 1 1992.1025 1983.3354 cm
0 0 m
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0 6.56 l
h
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0 0 0 0.7 K
0.841 w
q 1 0 0 1 2024.6885 1993.2061 cm
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34.588 0 l
S
Q
q
1790.252 1546.923 657.435 534.413 re
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q 1 0 0 1 2026.8871 1993.1228 cm
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1 0.6 0.1 0.53 k
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0 0 m
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h
f
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1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 2003.1509 1977.468 cm
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h
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0 0 0 0.7 K
0.841 w
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S
Q
0.28 0 1 0 k
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f
0.28 0 1 0 K
1.121 w
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h
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q
1790.252 1546.923 657.435 534.413 re
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h
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h
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1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 1987.1594 1949.1982 cm
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h
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0.841 w
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Q
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f
0.28 0 1 0 K
1.121 w
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h
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q
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h
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h
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0.28 0 1 0 K
1.121 w
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h
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0.841 w
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-2.722 4.74 l
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h
S
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0 0 0 0.7 K
0.841 w
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75.124 0 l
S
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0.28 0 1 0 k
2009.73 1705.012 -4.456 4.581 re
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0.28 0 1 0 K
1.121 w
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0 0 m
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h
S
Q
0 0 0 0.7 K
0.841 w
q 1 0 0 1 1970.9286 1713.6351 cm
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37.65 0 l
S
Q
q
1790.252 1546.923 657.435 534.413 re
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0.16 1 0.11 0.43 k
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0.16 1 0.11 0.43 K
0.63 w 1 j
q 1 0 0 1 1973.0293 1713.5518 cm
0 0 m
0 -1.182 -0.941 -2.138 -2.101 -2.138 c
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-4.201 1.181 -3.26 2.138 -2.101 2.138 c
-0.941 2.138 0 1.181 0 0 c
h
S
Q
Q
q 1 0 0 1 1952.542 1700.6556 cm
0 0 m
-11.558 0 l
0 0 m
22.415 0 l
S
Q
1 0.6 0.1 0.53 k
q 1 0 0 1 1955.3516 1698.6688 cm
0 0 m
-2.722 4.74 l
-5.444 0 l
h
f
Q
1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 1955.3516 1698.6688 cm
0 0 m
-2.722 4.74 l
-5.444 0 l
0 0 l
h
S
Q
0 0 0 0.7 K
0.841 w
q 1 0 0 1 2032.2188 1686.1182 cm
0 0 m
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0 0 m
79.676 0 l
S
Q
0.28 0 1 0 k
2034.608 1683.958 -4.456 4.582 re
f
0.28 0 1 0 K
1.121 w
q 1 0 0 1 2034.6084 1683.9576 cm
0 0 m
-4.456 0 l
-4.456 4.582 l
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h
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0 0 0 0.7 K
0.841 w
q 1 0 0 1 2004.5507 1692.6077 cm
0 0 m
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50.082 0 l
S
Q
q
1790.252 1546.923 657.435 534.413 re
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0.16 1 0.11 0.43 k
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-4.201 1.181 -3.26 2.138 -2.101 2.138 c
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0.16 1 0.11 0.43 K
0.63 w 1 j
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-4.201 1.181 -3.26 2.138 -2.101 2.138 c
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h
S
Q
Q
q 1 0 0 1 1961.1223 1679.4252 cm
0 0 m
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0 0 m
21.539 0 l
S
Q
1 0.6 0.1 0.53 k
q 1 0 0 1 1964.0276 1677.4004 cm
0 0 m
-2.722 4.739 l
-5.444 0 l
h
f
Q
1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 1964.0276 1677.4004 cm
0 0 m
-2.722 4.739 l
-5.444 0 l
0 0 l
h
S
Q
0 0 0 0.7 K
0.841 w
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92.635 0 l
S
Q
0.28 0 1 0 k
2018.803 1663.525 -4.456 4.582 re
f
0.28 0 1 0 K
1.121 w
q 1 0 0 1 2018.8032 1663.5254 cm
0 0 m
-4.456 0 l
-4.456 4.582 l
0 4.582 l
h
S
Q
0 0 0 0.7 K
0.841 w
q 1 0 0 1 2018.3848 1672.1912 cm
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75.649 0 l
S
Q
q
1790.252 1546.923 657.435 534.413 re
W n
0.16 1 0.11 0.43 k
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0 0 m
0 -1.182 -0.941 -2.138 -2.101 -2.138 c
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-4.202 1.181 -3.26 2.138 -2.101 2.138 c
-0.941 2.138 0 1.181 0 0 c
f
Q
0.16 1 0.11 0.43 K
0.63 w 1 j
q 1 0 0 1 2020.4852 1672.1077 cm
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h
S
Q
Q
q 1 0 0 1 1974.0809 1659.2124 cm
0 0 m
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39.4 0 l
S
Q
1 0.6 0.1 0.53 k
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0 0 m
-2.722 4.74 l
-5.443 0 l
h
f
Q
1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 1976.8904 1657.1111 cm
0 0 m
-2.722 4.74 l
-5.443 0 l
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h
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0 0 0 0.7 K
0.841 w
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86.33 0 l
S
Q
0.28 0 1 0 k
2005.98 1642.277 -4.455 4.581 re
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0.28 0 1 0 K
1.121 w
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0 0 m
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-4.455 4.581 l
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h
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Q
0 0 0 0.7 K
0.841 w
q 1 0 0 1 1959.3715 1651.1451 cm
0 0 m
-16.636 0 l
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35.723 0 l
S
Q
q
1790.252 1546.923 657.435 534.413 re
W n
0.16 1 0.11 0.43 k
q 1 0 0 1 1961.472 1651.0618 cm
0 0 m
0 -1.182 -0.941 -2.138 -2.101 -2.138 c
-3.26 -2.138 -4.202 -1.182 -4.202 0 c
-4.202 1.181 -3.26 2.138 -2.101 2.138 c
-0.941 2.138 0 1.181 0 0 c
f
Q
0.16 1 0.11 0.43 K
0.63 w 1 j
q 1 0 0 1 1961.472 1651.0618 cm
0 0 m
0 -1.182 -0.941 -2.138 -2.101 -2.138 c
-3.26 -2.138 -4.202 -1.182 -4.202 0 c
-4.202 1.181 -3.26 2.138 -2.101 2.138 c
-0.941 2.138 0 1.181 0 0 c
h
S
Q
Q
q 1 0 0 1 1946.7632 1638.1663 cm
0 0 m
-10.332 0 l
0 0 m
22.939 0 l
S
Q
1 0.6 0.1 0.53 k
q 1 0 0 1 1949.5728 1636.1558 cm
0 0 m
-2.722 4.74 l
-5.443 0 l
h
f
Q
1 0.6 0.1 0.53 K
1.121 w
q 1 0 0 1 1949.5728 1636.1558 cm
0 0 m
-2.722 4.74 l
-5.443 0 l
0 0 l
h
S
Q
BT
0 0 0 1 k
/T1_4 1 Tf
11.2117 0 0 11.2117 1794.2072 2046.0007 Tm
(\021\255\020)Tj
/T1_3 1 Tf
8.9694 0 0 8.9694 1980.7789 1893.7928 Tm
(\003\201)Tj
0 -30.312 TD
(\003\201)Tj
0 -2.298 TD
(\003\201)Tj
ET
q
1790.252 1546.923 657.435 534.413 re
W n
0.16 1 0.11 0.43 k
q 1 0 0 1 2081.8521 2025.2037 cm
0 0 m
0 -1.673 -1.354 -3.028 -3.025 -3.028 c
-4.696 -3.028 -6.05 -1.673 -6.05 0 c
-6.05 1.672 -4.696 3.029 -3.025 3.029 c
-1.354 3.029 0 1.672 0 0 c
f
Q
0.16 1 0.11 0.43 K
0.63 w 1 j
q 1 0 0 1 2081.8521 2025.2037 cm
0 0 m
0 -1.673 -1.354 -3.028 -3.025 -3.028 c
-4.696 -3.028 -6.05 -1.673 -6.05 0 c
-6.05 1.672 -4.696 3.029 -3.025 3.029 c
-1.354 3.029 0 1.672 0 0 c
h
S
Q
Q
0.28 0 1 0 k
2003.784 2015.421 -6.418 6.55 re
f
0.28 0 1 0 K
q 1 0 0 1 2003.7841 2015.4211 cm
0 0 m
-6.418 0 l
-6.418 6.55 l
0 6.55 l
h
S
Q
BT
0 0 0 1 k
/GS1 gs
/T1_1 1 Tf
0 Tc 0 Tw 16 0 0 16 1787.969 1513.2797 Tm
[(CEIs listed as NC wer)18(e not calculated because of the small number of events per cell )]TJ
0 -1.2 TD
[(\(<3\035patients per gr)18(oup\). An OR of >1 favors the second drug in the comparison. AML, acute \
)]TJ
0 -1.2 TD
[(myeloid leukemia; MDS, myelodysplastic syndr)18(omes; NC, not calculable)]TJ
ET
0.523 0 0.142 0 k
/GS0 gs
1786.053 1336.948 283.947 -56.124 re
f
2070 1336.948 125.624 -56.124 re
2195.624 1336.948 125.624 -56.124 re
2321.249 1336.948 125.624 -56.124 re
f
0.086 0.039 0.03 0 k
1786.053 1280.824 283.947 -101.86 re
2070 1280.824 125.624 -101.86 re
2195.624 1280.824 125.624 -101.86 re
2321.249 1280.824 125.624 -101.86 re
1786.053 1101.105 283.947 -53.86 re
2070 1101.105 125.624 -53.86 re
2195.624 1101.105 125.624 -53.86 re
2321.249 1101.105 125.624 -53.86 re
1786.053 969.385 283.947 -77.86 re
2070 969.385 125.624 -77.86 re
2195.624 969.385 125.624 -77.86 re
2321.249 969.385 125.624 -77.86 re
f
0 0 0 0 k
1786.053 1178.964 283.947 -77.86 re
2070 1178.964 125.624 -77.86 re
2195.624 1178.964 125.624 -77.86 re
2321.249 1178.964 125.624 -77.86 re
1786.053 1047.245 283.947 -77.86 re
2070 1047.245 125.624 -77.86 re
2195.624 1047.245 125.624 -77.86 re
2321.249 1047.245 125.624 -77.86 re
f
0 0 0 0 K
1 w
/GS2 gs
q 1 0 0 1 2070 1281.324 cm
0 0 m
0 55.624 l
S
Q
q 1 0 0 1 2195.6243 1281.324 cm
0 0 m
0 55.624 l
S
Q
q 1 0 0 1 2321.2485 1281.324 cm
0 0 m
0 55.624 l
S
Q
q 1 0 0 1 2446.8728 1281.324 cm
0 0 m
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S
Q
q 1 0 0 1 1786.053 1280.824 cm
0 0 m
283.947 0 l
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Q
q 1 0 0 1 2070 1280.824 cm
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125.624 0 l
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Q
q 1 0 0 1 2070 1179.4644 cm
0 0 m
0 100.86 l
S
Q
q 1 0 0 1 2195.6243 1280.824 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2195.6243 1179.4644 cm
0 0 m
0 100.86 l
S
Q
q 1 0 0 1 2321.2485 1280.824 cm
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126.124 0 l
S
Q
q 1 0 0 1 2321.2485 1179.4644 cm
0 0 m
0 100.86 l
S
Q
q 1 0 0 1 2446.8728 1179.4644 cm
0 0 m
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S
Q
q 1 0 0 1 1786.053 1178.9644 cm
0 0 m
283.947 0 l
S
Q
q 1 0 0 1 2070 1178.9644 cm
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125.624 0 l
S
Q
q 1 0 0 1 2070 1101.6046 cm
0 0 m
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S
Q
q 1 0 0 1 2195.6243 1178.9644 cm
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125.624 0 l
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Q
q 1 0 0 1 2195.6243 1101.6046 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 2321.2485 1178.9644 cm
0 0 m
126.124 0 l
S
Q
q 1 0 0 1 2321.2485 1101.6046 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 2446.8728 1101.6046 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 1786.053 1101.1046 cm
0 0 m
283.947 0 l
S
Q
q 1 0 0 1 2070 1101.1046 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2070 1047.745 cm
0 0 m
0 52.86 l
S
Q
q 1 0 0 1 2195.6243 1101.1046 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2195.6243 1047.745 cm
0 0 m
0 52.86 l
S
Q
q 1 0 0 1 2321.2485 1101.1046 cm
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126.124 0 l
S
Q
q 1 0 0 1 2321.2485 1047.745 cm
0 0 m
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S
Q
q 1 0 0 1 2446.8728 1047.745 cm
0 0 m
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S
Q
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0 0 m
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S
Q
q 1 0 0 1 2070 1047.245 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2070 969.8853 cm
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S
Q
q 1 0 0 1 2195.6243 1047.245 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2195.6243 969.8853 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 2321.2485 1047.245 cm
0 0 m
126.124 0 l
S
Q
q 1 0 0 1 2321.2485 969.8853 cm
0 0 m
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S
Q
q 1 0 0 1 2446.8728 969.8853 cm
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Q
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Q
q 1 0 0 1 2070 969.3853 cm
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125.624 0 l
S
Q
q 1 0 0 1 2070 892.0256 cm
0 0 m
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S
Q
q 1 0 0 1 2195.6243 969.3853 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2195.6243 892.0256 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 2321.2485 969.3853 cm
0 0 m
126.124 0 l
S
Q
q 1 0 0 1 2321.2485 892.0256 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 2446.8728 892.0256 cm
0 0 m
0 76.86 l
S
Q
q 1 0 0 1 1786.053 891.5256 cm
0 0 m
283.947 0 l
S
Q
q 1 0 0 1 2070 891.5256 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2195.6243 891.5256 cm
0 0 m
125.624 0 l
S
Q
q 1 0 0 1 2321.2485 891.5256 cm
0 0 m
126.124 0 l
S
Q
BT
0 0 0 1 k
/GS1 gs
/T1_0 1 Tf
18 0 0 18 2096.3354 1315.5927 Tm
(Olaparib)Tj
0.226 -1.222 Td
(\(N=303\))Tj
6.577 1.222 Td
(Niraparib)Tj
0.402 -1.222 Td
(\(N=348\))Tj
6.327 1.222 Td
(Rucaparib)Tj
0.652 -1.222 Td
(\(N=162\))Tj
-30.95 -1.896 Td
(Demographic characteristics*)Tj
/T1_1 1 Tf
0 -1.333 TD
(Age, years)Tj
0.787 -1.333 Td
(Mean \(SD\))Tj
T*
(Median [IQR])Tj
15.661 1.333 Td
(58.4 \(10.3\))Tj
T*
(59.0 [11.0])Tj
7.257 1.333 Td
(59.4 \(9.4\))Tj
-0.278 -1.333 Td
(59.0 [11.0])Tj
7.257 1.333 Td
(58.3 \(8.5\))Tj
-0.278 -1.333 Td
(58.0 [10.0])Tj
-30.406 -1.659 Td
[(Payer)92(, n \(%\))]TJ
0.787 -1.333 Td
[(Commer)18(cial)]TJ
T*
[(Medicar)18(e Supplemental)]TJ
15.8 1.333 Td
(243 \(80.2\))Tj
0.278 -1.333 Td
(60 \(19.8\))Tj
6.701 1.333 Td
(271 \(77.9\))Tj
0.278 -1.333 Td
(77 \(22.1\))Tj
6.701 1.333 Td
(135 \(83.3\))Tj
0.278 -1.333 Td
(27 \(16.7\))Tj
-30.823 -1.659 Td
(Duration of follow-up, months)Tj
0.787 -1.333 Td
(Median [IQR])Tj
16.217 0 Td
[(7.4 [9.6])-3125(9.7 [11.1])-3125(8.7 [9.0])]TJ
/T1_0 1 Tf
-17.004 -1.659 Td
(Clinical characteristics)Tj
10.494 0 0 10.494 1990.7714 1031.8833 Tm
(\206)Tj
/T1_1 1 Tf
18 0 0 18 1794.5569 1001.8893 Tm
(Mean NCI-adapted Charlson )Tj
T*
(Comorbidity Index \(SD\))Tj
17.004 1.333 Td
[(0.7 \(1.0\))-3403(0.9 \(1.1\))-3403(0.8 \(1.1\))]TJ
-17.004 -2.992 Td
[(Baseline tr)18(eatment history)74(, n \(%\))]TJ
0.787 -1.333 Td
(Systemic chemotherapy)Tj
T*
[(Cancer)55(-r)18(elated sur)28(gery)]TJ
15.8 1.333 Td
(269 \(88.8\))Tj
T*
(205 \(67.7\))Tj
6.979 1.333 Td
(315 \(90.5\) )Tj
T*
(250 \(71.8\))Tj
6.979 1.333 Td
(146 \(90.1\))Tj
T*
(110 \(67.9\))Tj
16 0 0 16 1786.053 870.1564 Tm
[(*Demographic characteristics wer)18(e measur)18(ed on the date of \037rst P)74(ARPi pr)18(escription \(index )]TJ
0 -1.2 TD
(date\); )Tj
9.328 0 0 9.328 1830.804 856.2844 Tm
(\206)Tj
16 0 0 16 1835.9904 850.9564 Tm
[(Clinical characteristics wer)18(e measur)18(ed during the 6-month baseline period excluding )]TJ
-3.121 -1.2 Td
[(baseline tr)18(eatment history)74(, which was based on all available patient data in the patient )]TJ
T*
[(history)74(. IQR, inter)18(quartile range; NCI, National Cancer Institute)]TJ
ET
1 0.748 0.382 0.261 k
/GS0 gs
1785.372 1357.736 662.001 82.588 re
f
1 0.748 0.382 0.261 K
55 w
q 1 0 0 1 1785.3719 1413.1156 cm
0 0 m
662.001 0 l
S
Q
BT
0 0 0 0 k
/T1_0 1 Tf
22 0 0 22 1805.3719 1403.6156 Tm
[(T)111(able 1. Baseline demographics and clinical characteristics )]TJ
0 -1.136 TD
[(of patients with ovarian cancer by P)74(ARPi tr)18(eatment gr)18(oup)]TJ
0 0 0 1 k
/T1_5 1 Tf
10.3485 0 0 10.3485 1837.1895 441.1323 Tm
(\037)Tj
3.432 -1.104 Td
(\036\035\034\033\034\032\031\030)Tj
0.144 -1.2 Td
(\027\026\025\024\023\022\021)Tj
0.281 18.259 Td
(\020\022\017\022\016)Tj
-0.198 -1.2 Td
(\027\r\025\024\037\023\021)Tj
ET
0 0 0 1 K
0.647 w
q 1 0 0 1 2024.3115 441.132 cm
0 0 m
0 3.214 l
S
Q
q 1 0 0 1 1936.568 441.132 cm
0 0 m
0 3.214 l
S
Q
q 1 0 0 1 1848.4814 441.132 cm
0 0 m
0 3.214 l
S
Q
q 1 0 0 1 1845.2679 444.3464 cm
0 0 m
3.213 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 1831.4354 480.4066 Tm
(\022\037)Tj
ET
q 1 0 0 1 1845.2679 483.6205 cm
0 0 m
3.213 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 1831.4354 519.7968 Tm
(\f\037)Tj
ET
q 1 0 0 1 1845.2679 523.0103 cm
0 0 m
3.213 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 1831.4354 558.5632 Tm
(\020\037)Tj
ET
q 1 0 0 1 1845.2679 561.7772 cm
0 0 m
3.213 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 1831.4354 597.8753 Tm
(\013\037)Tj
ET
q 1 0 0 1 1845.2679 601.0894 cm
0 0 m
3.213 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 1825.6825 636.8678 Tm
(\024\037\037)Tj
0 10.3485 -10.3485 0 1814.0431 425.8944 Tm
(\n\034\t\031\b\r\t\007\006\033\b\032\007\031\007\t\b\r\t\006\005\031\t\004\
\006\031\r\003\b\002\006\n\001\n\031\006\032\b\201\031\215\b\r\006\027\016\
\021)Tj
ET
q 1 0 0 1 1845.2679 640.0812 cm
0 0 m
3.213 0 l
S
Q
q 1 0 0 1 2112.1353 441.132 cm
0 0 m
0 3.214 l
S
Q
0.16 1 0.11 0.43 k
1906.158 444.347 -27.607 121.794 re
f
q 1 0 0 1 1892.3545 580.3899 cm
0 0 m
0 -29.36 l
S
Q
q 1 0 0 1 1890.334 580.3899 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 1890.334 551.0297 cm
0 0 m
4.041 0 l
S
Q
BT
0 0 0 1 k
/T1_5 1 Tf
10.3485 0 0 10.3485 1959.1365 429.7063 Tm
(\026\031\032\034\033\034\032\031\030)Tj
0.292 -1.2 Td
(\027\026\025\022\217\024\021)Tj
14.2291 0 0 14.2291 1791.066 669.5416 Tm
(\001)Tj
23.149 0 Td
(\220)Tj
10.3485 0 0 10.3485 1965.0654 553.2841 Tm
(\235\217\017\240\016)Tj
-0.448 -1.2 Td
(\027\r\025\240\037\021\255\255\255)Tj
ET
0.28 0 1 0 k
1994.112 444.347 -27.607 70.914 re
f
q 1 0 0 1 1980.3083 527.1506 cm
0 0 m
0 -23.779 l
S
Q
q 1 0 0 1 1978.2878 527.1506 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 1978.2878 503.3713 cm
0 0 m
4.041 0 l
S
Q
BT
0 0 0 1 k
/T1_5 1 Tf
10.3485 0 0 10.3485 2044.4982 429.7063 Tm
(\200\202\034\033\034\032\031\030)Tj
0.542 -1.2 Td
(\027\026\025\024\024\023\021)Tj
0.281 16.12 Td
(\f\013\017\023\016)Tj
-0.258 -1.2 Td
(\027\r\025\217\023\021\255)Tj
6.0332 0 0 6.0332 2082.8215 575.1344 Tm
(\203)Tj
ET
1 0.6 0.1 0.53 k
2082.066 444.347 -27.607 95.685 re
f
q 1 0 0 1 2068.2622 558.5637 cm
0 0 m
0 -37.908 l
S
Q
q 1 0 0 1 2066.2417 558.5637 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 2066.2417 520.6556 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 1848.4814 640.0812 cm
0 0 m
0 -195.735 l
263.653 -195.735 l
S
Q
BT
0 0 0 1 k
/T1_5 1 Tf
10.3485 0 0 10.3485 2167.9004 441.1323 Tm
(\037)Tj
3.432 -1.104 Td
(\036\035\034\033\034\032\031\030)Tj
0.144 -1.2 Td
(\027\026\025\024\023\022\021)Tj
0.281 21.334 Td
(\013\037\017\022\016)Tj
-0.198 -1.2 Td
(\027\r\025\024\235\013\021)Tj
ET
q 1 0 0 1 2355.0225 441.132 cm
0 0 m
0 3.214 l
S
Q
q 1 0 0 1 2267.2788 441.132 cm
0 0 m
0 3.214 l
S
Q
q 1 0 0 1 2179.1931 441.132 cm
0 0 m
0 3.214 l
S
Q
q 1 0 0 1 2175.978 444.3464 cm
0 0 m
3.215 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 2162.1462 480.4066 Tm
(\022\037)Tj
ET
q 1 0 0 1 2175.978 483.6205 cm
0 0 m
3.215 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 2162.1462 519.7968 Tm
(\f\037)Tj
ET
q 1 0 0 1 2175.978 523.0103 cm
0 0 m
3.215 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 2162.1462 558.5632 Tm
(\020\037)Tj
ET
q 1 0 0 1 2175.978 561.7772 cm
0 0 m
3.215 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 2162.1462 597.8753 Tm
(\013\037)Tj
ET
q 1 0 0 1 2175.978 601.0894 cm
0 0 m
3.215 0 l
S
Q
BT
/T1_5 1 Tf
10.3485 0 0 10.3485 2156.3936 636.8678 Tm
(\024\037\037)Tj
0 10.3485 -10.3485 0 2144.7539 475.9074 Tm
(\n\034\031\t\b\r\t\007\006\005\031\t\004\006\204\n\006\205\037\017\013\006\
\027\016\021)Tj
ET
q 1 0 0 1 2175.978 640.0812 cm
0 0 m
3.215 0 l
S
Q
q 1 0 0 1 2442.8452 441.132 cm
0 0 m
0 3.214 l
S
Q
0.16 1 0.11 0.43 k
2236.869 444.347 -27.607 157.13 re
f
q 1 0 0 1 2223.0654 612.2728 cm
0 0 m
0 -23.983 l
S
Q
q 1 0 0 1 2221.0442 612.2728 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 2221.0442 588.2908 cm
0 0 m
4.041 0 l
S
Q
BT
0 0 0 1 k
/T1_5 1 Tf
10.3485 0 0 10.3485 2289.8474 429.7063 Tm
(\026\031\032\034\033\034\032\031\030)Tj
0.292 -1.2 Td
(\027\026\025\022\217\024\021)Tj
0.281 13.646 Td
(\235\013\017\020\016)Tj
-0.448 -1.2 Td
(\027\r\025\240\023\021\255\255\255)Tj
ET
0.28 0 1 0 k
2324.823 444.347 -27.608 76.03 re
f
q 1 0 0 1 2311.02 532.6268 cm
0 0 m
0 -24.5 l
S
Q
q 1 0 0 1 2308.9988 532.6268 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 2308.9988 508.1269 cm
0 0 m
4.041 0 l
S
Q
BT
0 0 0 1 k
/T1_5 1 Tf
10.3485 0 0 10.3485 2375.209 429.7063 Tm
(\200\202\034\033\034\032\031\030)Tj
0.542 -1.2 Td
(\027\026\025\024\024\023\021)Tj
0.281 18.701 Td
(\020\235\017\022\016)Tj
-0.758 -1.2 Td
(\027\r\025\023\f\021\255\255)Tj
6.0332 0 0 6.0332 2412.0002 601.8394 Tm
(\203\203\203)Tj
ET
1 0.6 0.1 0.53 k
2412.776 444.347 -27.607 124.121 re
f
q 1 0 0 1 2398.9731 584.9274 cm
0 0 m
0 -34.868 l
S
Q
q 1 0 0 1 2396.9531 584.9274 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 2396.9531 550.0601 cm
0 0 m
4.041 0 l
S
Q
q 1 0 0 1 2179.1931 640.0812 cm
0 0 m
0 -195.735 l
263.652 -195.735 l
S
Q
BT
0 0 0 1 k
/GS1 gs
/T1_1 1 Tf
-0.02 Tc 16 0 0 16 1784.9312 378.6769 Tm
[(\(A\) Persistence: per)18(centage of patients with no index P)74(ARPi r)18(egimen tr)18(eatment gaps of)-20( )]TJ
0 -1.2 TD
[(>90\035days out of those with at least 6 months of continuous enr)18(ollment.)]TJ
0.02 Tw 9.328 0 0 9.328 2266.2046 364.8049 Tm
(11)Tj
0 Tw 16 0 0 16 2276.2041 359.4769 Tm
[( \(B\) Adher)18(ence: MPR)-20( )]TJ
-30.705 -1.2 Td
[(was measur)18(ed as the ratio of the sum of days\222 supply during the \037xed 6-month\
\(180-day\))-20( )]TJ
T*
[(follow-up period, and patients with MPR <80% wer)18(e categorized as non-adher)18(ent.)]TJ
0.02 Tw 9.328 0 0 9.328 2349.4661 326.4049 Tm
(11)Tj
0 Tw 16 0 0 16 2359.4656 321.0769 Tm
[( Err)18(or)-20( )]TJ
-35.908 -1.2 Td
[(bars r)18(epr)18(esent 95% Clopper\226Pearson CI. *)]TJ
/T1_6 1 Tf
0 Tc (P)Tj
/T1_1 1 Tf
-0.02 Tc 18.868 0 Td
(<0.05 versus olaparib; **)Tj
/T1_6 1 Tf
0 Tc (P)Tj
/T1_1 1 Tf
-0.02 Tc 11.027 0 Td
[(<0.01 versus olaparib;)-20( )]TJ
0.02 Tw -29.895 -1.2 Td
(***)Tj
/T1_6 1 Tf
0 Tc 0 Tw (P)Tj
/T1_1 1 Tf
-0.02 Tc 1.624 0 Td
(<0.001 versus olaparib; )Tj
0 Tc 9.328 0 0 9.328 1975.2483 288.0049 Tm
(\206)Tj
/T1_6 1 Tf
16 0 0 16 1980.248 282.6769 Tm
(P)Tj
/T1_1 1 Tf
-0.02 Tc 0.628 0 Td
(<0.05 versus niraparib; )Tj
0.02 Tw 9.328 0 0 9.328 2150.7739 288.0049 Tm
(\206\206\206)Tj
/T1_6 1 Tf
0 Tc 0 Tw 16 0 0 16 2165.7734 282.6769 Tm
(P)Tj
/T1_1 1 Tf
-0.02 Tc 0.628 0 Td
[(<0.001 versus niraparib)-20( )]TJ
ET
1 0.748 0.382 0.261 k
/GS0 gs
1784.931 703 662.001 75 re
f
1 0.748 0.382 0.261 K
55 w
q 1 0 0 1 1784.9312 750.0783 cm
0 0 m
662.001 0 l
S
Q
BT
0 0 0 0 k
/T1_0 1 Tf
0 Tc 23 0 0 23 1804.9312 744.5783 Tm
[(Figur)18(e 2. Persistence and adher)18(ence to index P)74(ARPi )]TJ
0 -1.087 TD
[(r)18(egimen )]TJ
ET
q
0 0 3200 2400 re
W n
0.415 1 0.4 0.219 K
71 w
q 1 0 0 1 2473.9614 2173.2168 cm
0 0 m
665.039 0 l
S
Q
Q
BT
/T1_0 1 Tf
40 0 0 40 2493.9614 2158.7168 Tm
(Results)Tj
0.415 1 0.4 0.219 k
/T1_2 1 Tf
20 0 0 20 2475.8291 2103.9197 Tm
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(A total of 813 P)Tj
6.633 0 Td
[(ARPi-tr)18(eated patients with OC wer)18(e included; 303, 348, )]TJ
-6.633 -1.2 Td
[(and 162 r)18(eceived olaparib, niraparib, and rucaparib, r)18(espectively. )]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(At baseline, patient demographics and clinical characteristics wer)Tj
27.989 0 Td
(e similar )Tj
-27.989 -1.2 Td
[(acr)18(oss tr)18(eatment gr)18(oups \(T)111(able 1 and Supplementary T)111(able 2\).)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0.7 0.675 0.639 0.747 k
1.276 0 Td
(The pr)Tj
2.761 0 Td
(evalence of CEIs during the follow-up period after the \037rst initiatio\
n )Tj
-2.761 -1.2 Td
[(of P)74(ARPi is pr)18(ovided in the Supplementary Materials.)]TJ
0 0 0 1 k
/GS1 gs
( Risk of experiencing )Tj
0 -1.2 TD
(any CEI was higher with niraparib versus olaparib \(OR 3.36 [95% CI )Tj
T*
(2.00\2265.65]\) and with niraparib versus rucaparib \(2.09 [1.10\2263.95\
]\); the )Tj
T*
[(dif)18(fer)18(ence between rucaparib and olaparib was not statistically signi\037cant \
)]TJ
T*
(\(1.61 [0.93\2262.79]\). )Tj
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Risk of experiencing a hematologic CEI was higher with niraparib versus \
)Tj
T*
(olaparib \(OR 2.13 [95% CI 1.55\2262.92]\) and with niraparib versus ruc\
aparib )Tj
T*
(\(1.58 [1.08\2262.30]\); again, the dif)Tj
13.638 0 Td
[(fer)18(ence between rucaparib and olaparib )]TJ
-13.638 -1.2 Td
[(was not statistically signi\037cant \(1.35 [0.92\2261.98]; Figur)18(e 1\). )]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
-0.01 Tc 1.276 0 Td
(Multivariate analysis, adjusting for )Tj
/T1_7 1 Tf
(a priori )Tj
/T1_2 1 Tf
[(confounders \(de\037ned in the)-10( )]TJ
0 Tc T*
[(M)10(e)10(t)10(h)10(o)10(d)10(s)10(\))10(,)10( con\037rmed that ther)18(e was a gr)18(eater pr)18(obability of any CEI with )]TJ
T*
[(niraparib versus olaparib \(hazar)18(d ratio [HR] 1.35 [95% CI 1.14\2261.59]\); )]TJ
T*
[(no dif)18(fer)18(ence was observed between rucaparib and olaparib \(1.16 )]TJ
T*
([0.94\2261.43]\) and niraparib and rucaparib \(1.16 [0.95\2261.41]\). )Tj
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
[(Overall, 89.4% \(n=271/303\), 69.3% \(n=241/348\), and 93.2% \(n=151/162\
\) )183( )]TJ
T*
(of patients r)Tj
5.075 0 Td
[(eceiving olaparib, niraparib, and rucaparib, r)18(espectively, )]TJ
-5.075 -1.2 Td
(started at the highest indicated dose.)Tj
/CS0 cs 1 scn
/GS0 gs
( )Tj
0 0 0 1 k
/GS1 gs
( )Tj
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Dose decr)Tj
4.428 0 Td
[(eases wer)18(e the most common dose adjustment and wer)18(e )]TJ
-0.01 Tc -4.428 -1.2 Td
[(observed in 21.1% \(n=64/303\), 35.1% \(n=122/348\), and 30.2% \(n=49/16\
2\))-10( )]TJ
0 Tc 31.897 0 Td
( )Tj
-31.897 -1.2 Td
[(of olaparib-, niraparib-, and rucaparib-tr)18(eated patients, r)18(espectively. )]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(In the subgr)Tj
5.112 0 Td
(oup of patients with at least 6 months of medical claims )Tj
-5.112 -1.2 Td
[(information following P)74(ARPi initiation, the pr)18(oportion persistent on index )]TJ
T*
[(P)74(ARPi \(de\037ned in the Methods\) was 62.2% \(n=107/172\) with olaparib,\
)]TJ
T*
[(compar)18(ed with 35.9% with niraparib \(n=90/251, )]TJ
/T1_7 1 Tf
(P)Tj
/T1_2 1 Tf
(<0.001\) and 48.7% )Tj
T*
(with rucaparib \(n=57/117, )Tj
/T1_7 1 Tf
(P)Tj
/T1_2 1 Tf
[(=0.023; Figur)18(e 2\) )]TJ
0 -1.7 TD
(\226)Tj
( )Tj
1.276 0 Td
(The pr)Tj
2.761 0 Td
[(oportion of patients adher)18(ent \(de\037ned in the Methods\) to their )]TJ
-2.761 -1.2 Td
[(index P)74(ARPi r)18(egimen was 80.2% for patients r)18(eceiving olaparib, )]TJ
0 -1.2 TD
[(compar)18(ed with 38.6% \()]TJ
/T1_7 1 Tf
(P)Tj
/T1_2 1 Tf
[(<0.001\) for patients r)18(eceiving niraparib and )]TJ
T*
(63.2% \()Tj
/T1_7 1 Tf
(P)Tj
/T1_2 1 Tf
[(=0.001\) for patients r)18(eceiving rucaparib \(Figur)18(e 2\).)]TJ
/CS0 cs 1 scn
/GS0 gs
-2.551 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Multivariate analysis, adjusting for )Tj
/T1_7 1 Tf
(a priori)Tj
/T1_2 1 Tf
( confounders \(de\037ned in the )Tj
T*
[(Methods\), con\037rmed that ther)18(e was a gr)18(eater pr)18(obability of discontinuing )]TJ
T*
[(tr)18(eatment with niraparib \(HR 1.52 [95% CI 1.24\2261.86]\) or rucaparib )]TJ
0 -1.25 TD
(\(1.42 [1.11\2261.81]\) than with olaparib.)Tj
ET
q
0 0 3200 2400 re
W n
0.415 1 0.4 0.219 K
71 w
/GS0 gs
q 1 0 0 1 2473.6157 1068.3423 cm
0 0 m
665.039 0 l
S
Q
Q
BT
0 0 0 0 k
/GS0 gs
/T1_0 1 Tf
40 0 0 40 2493.6157 1053.8423 Tm
[(Str)18(engths and limitations)]TJ
/CS0 cs 1 scn
/T1_2 1 Tf
20 0 0 20 2475.2075 997.4146 Tm
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(T)Tj
0.445 0 Td
[(o our knowledge, this is the largest r)18(eal-world comparison of P)74(ARPi )]TJ
-0.445 -1.2 Td
(therapy in women with OC.)Tj
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Leveraging claims data identi\037ed a large population of women with OC \
)Tj
0 -1.2 TD
(who wer)Tj
3.669 0 Td
[(e new P)74(ARPi users, capturing data r)18(elated to clinical events and )]TJ
-3.669 -1.2 Td
[(pr)18(escribing information \(eg healthcar)18(e visits, medication pr)18(escription\) )]TJ
0 -1.7 TD
(\226)Tj
( )Tj
1.276 0 Td
(By focusing on January 2017 to May 2019, we incr)Tj
21.936 0 Td
(eased the likelihood )Tj
-21.936 -1.2 Td
[(of capturing P)74(ARPi use in a maintenance setting.)]TJ
/CS0 cs 1 scn
/GS0 gs
-2.551 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Despite the limitations inher)Tj
11.778 0 Td
[(ent to observational and r)18(etr)18(ospective studies, )]TJ
-11.778 -1.2 Td
[(the use of claims data is well established in r)18(esear)18(ch examining tolerability )]TJ
0 -1.2 TD
[(and healthcar)18(e r)18(esour)18(ce utilization in many disease ar)18(eas.)]TJ
11.66 0 0 11.66 2993.8535 758.0746 Tm
(12\22614)Tj
20 0 0 20 3025.6155 751.4146 Tm
( )Tj
/CS0 cs 1 scn
/GS0 gs
-27.52 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Line of therapy was not r)Tj
10.633 0 Td
[(ecor)18(ded; it was also not known if the P)74(ARPi )]TJ
-10.633 -1.2 Td
[(pr)18(escriptions wer)18(e for maintenance or tr)18(eatment settings in OC, although )]TJ
T*
[(the vast majority of patients had pr)18(eviously r)18(eceived chemotherapy at )]TJ
T*
(baseline.)Tj
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Only CEIs that wer)Tj
7.965 0 Td
[(e sever)18(e enough to seek medical attention/needed )]TJ
-7.965 -1.2 Td
[(tr)18(eatment wer)18(e r)18(ecor)18(ded, but this is unlikely to be dif)18(fer)18(ential with r)18(espect )]TJ
T*
[(to the thr)18(ee P)74(ARPi. )]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(The lower observed starting dose for niraparib likely r)Tj
22.655 0 Td
(e\035ects modi\037ed )Tj
-22.655 -1.2 Td
[(dosing accor)18(ding to weight and platelet count for AE mitigation. )]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
-0.02 Tc 1.276 0 Td
(The dosing, adher)Tj
7.441 0 Td
[(ence and persistence r)18(esults r)18(e\035ect patter)-18(ns in pr)18(escription)-20( )]TJ
0 Tc 24.378 0 Td
( )Tj
-31.819 -1.2 Td
[(\037lls of the index medications and may not fully captur)18(e usage patter)-18(ns.)]TJ
/CS0 cs 1 scn
/GS0 gs
-1.276 -1.7 Td
(\225)Tj
( )Tj
0 0 0 1 k
/GS1 gs
1.276 0 Td
(Information on r)Tj
6.761 0 Td
(easons for discontinuation is unavailable.)Tj
ET
q
0 0 3200 2400 re
W n
0.415 1 0.4 0.219 K
71 w
/GS0 gs
q 1 0 0 1 2474.2373 356.4297 cm
0 0 m
665.039 0 l
S
Q
Q
BT
0 0 0 0 k
/GS0 gs
/T1_0 1 Tf
40 0 0 40 2494.2373 341.9297 Tm
[(Refer)18(ences)]TJ
0 0 0 1 k
/GS1 gs
/T1_2 1 Tf
-0.005 Tc 0.005 Tw 13 0 0 13 2473.8921 289.9213 Tm
(1.)Tj
0 Tc 0 Tw 0.829 0 Td
( )Tj
0.915 0 Td
(AstraZeneca. L)Tj
6.484 0 Td
(ynparza)Tj
7.579 0 0 7.579 2624.9297 294.2503 Tm
(\256)Tj
13 0 0 13 2630.9927 289.9213 Tm
( \(olaparib\) tablets, for )Tj
-10.34 -1.308 Td
[(oral use. US pr)18(escribing information. 2019. )]TJ
0 -1.308 TD
[(A)18(vailable at: https://www)55(.accessdata.fda.gov/)]TJ
T*
(drugsatfda_docs/label/2019/208558s009lbl.pdf )Tj
-1.744 -1.462 Td
(2.)Tj
( )Tj
1.744 0 Td
(T)Tj
0.445 0 Td
[(esar)18(o. Zejula \(niraparib\) capsules, for oral use. )]TJ
-0.445 -1.308 Td
[(US pr)18(escribing information. 2020. A)18(vailable at: )]TJ
T*
[(https://www)55(.gsksour)18(ce.com/pharma/content/)]TJ
T*
[(dam/GlaxoSmithKline/US/en/Pr)18(escribing_)]TJ
T*
[(Information/Zejula/pdf/ZEJULA-PI-PIL.PDF)129(.)]TJ
-1.744 -1.462 Td
(3.)Tj
( )Tj
1.744 0 Td
(Clovis Oncology. Rubraca)Tj
7.579 0 0 7.579 2641.791 137.2502 Tm
(\256)Tj
13 0 0 13 2647.854 132.9212 Tm
( \(rucaparib\) tablets, )Tj
-11.637 -1.308 Td
[(for oral use. US pr)18(escribing information. 2020. )]TJ
T*
[(A)18(vailable at: https://clovisoncology.com/pdfs/)]TJ
T*
(RubracaUSPI.pdf.)Tj
0 0 0 0 k
/GS0 gs
/T1_0 1 Tf
14 0 0 14 1786.053 166.9213 Tm
(Acknowledgments)Tj
0 0 0 1 k
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/T1_2 1 Tf
0 -1.214 TD
[(This study was funded by AstraZeneca and is part of an alliance between \
AstraZeneca)1( and Mer)18(ck Sharp & )]TJ
T*
[(Dohme Corp, a subsidiary of Mer)18(ck & Co, Inc, Kenilworth, NJ, USA. Medical writing assistance in the for\
m )]TJ
T*
[(of the pr)18(eparation and r)18(evision of the poster was funded by AstraZeneca and pr)18(ovided by Car)18(ol W)37(ar)18(eham, )]TJ
T*
[(MRes, PhD and Ben Dr)18(ever)92(, PhD of Comradis. Analytical support was funded by AstraZeneca and pr)18(ovided )]TJ
T*
[(by IBM W)37(atson Health\231. W)18(e thank W)-24(ill Sawyer and Miguel Miranda \(AstraZeneca\) for statistical support.)]TJ
ET
0.271 0.651 0.259 0.141 k
/GS0 gs
1030.395 303.541 -829.092 -137.439 re
f
BT
0 0 0 0 k
/T1_2 1 Tf
19 0 0 19 215.0846 264.6447 Tm
[(Scan to obtain the poster)92(, narrated poster)92(, Supplementary Materials and accompanying slide deck. )153( )]TJ
0 -1.158 TD
[(http://www)55(.astrazeneca-medimmuneoncologycongr)18(esses.com/2Y)92(a6ykf)]TJ
0 -1.474 TD
[(Copies of this e-poster obtained thr)18(ough QR, AR and/or text key codes ar)18(e for personal use only )]TJ
0 -1.158 TD
[(and may not be r)18(epr)18(oduced without written permission of the authors.)]TJ
/TT0 1 Tf
8.04 0 0 8.04 303.9986 234.9935 Tm
( )Tj
ET
q
64.182 166.102 137.121 137.439 re
W n
q
139.4575043 0 0 139.9400482 63.0106201 164.8428497 cm
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Q
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0.415 1 0.4 0.219 K
71 w
q 1 0 0 1 1786.0529 221.5109 cm
0 0 m
665.039 0 l
S
Q
BT
/T1_0 1 Tf
40 0 0 40 1806.0529 207.0109 Tm
(Funding and acknowledgments)Tj
0 0 0 1 k
/GS1 gs
/T1_2 1 Tf
13 0 0 13 2794.7053 288.9213 Tm
(4.)Tj
( )Tj
-0.004 Tw 1.744 0 Td
(Pujade-Lauraine E )Tj
/T1_7 1 Tf
(et al. Lancet Oncol)Tj
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( 2017;18:1274\22684.)Tj
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(5.)Tj
( )Tj
1.744 0 Td
(Coleman RL )Tj
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( 2017;390:1949\22661.)Tj
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(6.)Tj
( )Tj
1.744 0 Td
(Mirza MR )Tj
/T1_7 1 Tf
(et al. N Engl J Med)Tj
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( 2016;375:2154\22664.)Tj
-1.744 -1.462 Td
(7.)Tj
( )Tj
1.744 0 Td
(LaFargue CJ )Tj
/T1_7 1 Tf
(et al. Lancet Oncol)Tj
/T1_2 1 Tf
( 2019;20:e15\22628.)Tj
-1.744 -1.462 Td
(8.)Tj
( )Tj
1.744 0 Td
(Borr)Tj
1.835 0 Td
[(elli EP)153(, McGladrigan CG. )]TJ
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[(J Oncol Phar)-6(m Pract)]TJ
/T1_2 1 Tf
( )Tj
-1.835 -1.308 Td
(2020;26:1977\22686.)Tj
-1.744 -1.462 Td
(9.)Tj
( )Tj
1.744 0 Td
(Cecer)Tj
2.558 0 Td
(e SC )Tj
/T1_7 1 Tf
(et al. Gynecol Oncol)Tj
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( 2020;156:38\22644.)Tj
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(10.)Tj
( )Tj
1.744 0 Td
(Eakin CM )Tj
/T1_7 1 Tf
(et al. Gynecol Oncol)Tj
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( 2020;159:112\22617.)Tj
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(11.)Tj
( )Tj
1.744 0 Td
(Karve S )Tj
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(et al)Tj
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(. )Tj
/T1_7 1 Tf
(Curr Med Res Opin)Tj
/T1_2 1 Tf
( 2009;25:2303\22610.)Tj
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(12.)Tj
( )Tj
1.744 0 Td
(Pal S )Tj
/T1_7 1 Tf
(et al. BMC Cancer)Tj
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( 2019;19:548.)Tj
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(13.)Tj
( )Tj
1.744 0 Td
(Shah A )Tj
/T1_7 1 Tf
(et al. J Med Econ)Tj
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( 2020;23:330\22646.)Tj
-1.744 -1.462 Td
(14.)Tj
( )Tj
1.744 0 Td
(Hassett MJ )Tj
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(et al. J Natl Cancer Inst)Tj
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